Resection guided by antibodies (REGAJ): a diagnostic procedure during second-look operation in ovarian cancer patients

A hand-held probe has been used to localise the 131I-labelled antibody OC125 during second-look operation (SLO) in 22 ovarian cancer patients. In six patients microscopic cancer was detected with the procedure and a further six patients with areas of increased radioactivity during SLO developed recu...

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Bibliographic Details
Published in:British journal of cancer. Supplement 1990-07, Vol.10, p.18-20
Main Authors: Jäger, W, Feistel, H, Paterok, E M, Ronay, G, Tulusan, A H, Wolf, F, Lang, N
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Antigens, Tumor-Associated, Carbohydrate - analysis
Female
Humans
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - surgery
Radionuclide Imaging - methods
Reoperation
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Summary:A hand-held probe has been used to localise the 131I-labelled antibody OC125 during second-look operation (SLO) in 22 ovarian cancer patients. In six patients microscopic cancer was detected with the procedure and a further six patients with areas of increased radioactivity during SLO developed recurrent disease within 1-4 months. We suggest examining resection guided by antibodies as a possible means of removing antigen-producing cancerous tissues during surgery.
ISSN:0306-9443