Antibody transport and internalization into tumours

Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating intern...

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Bibliographic Details
Published in:British journal of cancer. Supplement 1990-07, Vol.10, p.1-5
Main Authors: Matzku, S, Moldenhauer, G, Kalthoff, H, Canevari, S, Colnaghi, M, Schuhmacher, J, Bihl, H
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - metabolism
Indium Radioisotopes
Iodine Radioisotopes
Liver - metabolism
Lymphoma - metabolism
Mice
Neoplasms, Experimental - metabolism
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Summary:Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.
ISSN:0306-9443