How WASP Regulates Actin Polymerization

To investigate which region of the NH2 terminus is required for inhibition, different domains were expressed and examined for their ability to bind and inhibit the activity of the VCA fragment. NH2-terminal fragments that include the GBD bind VCA and inhibit its activity.

Saved in:
Bibliographic Details
Published in:The Journal of cell biology 2000-09, Vol.150 (6), p.F117-F119
Main Author: Zigmond, Sally H.
Format: Article
Language:English
Subjects:
Actins
Actins - metabolism
Cell Physiological Phenomena
Cells
Cellular biology
Comment
Lymphocytes
Molecules
Neurons
Nucleation
Physiological regulation
Polymerization
Polymers
Polymers - metabolism
Profilins
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Receptors
Wiskott Aldrich syndrome
Wiskott-Aldrich Syndrome Protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate which region of the NH2 terminus is required for inhibition, different domains were expressed and examined for their ability to bind and inhibit the activity of the VCA fragment. NH2-terminal fragments that include the GBD bind VCA and inhibit its activity.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.150.6.F117