How WASP Regulates Actin Polymerization

To investigate which region of the NH2 terminus is required for inhibition, different domains were expressed and examined for their ability to bind and inhibit the activity of the VCA fragment. NH2-terminal fragments that include the GBD bind VCA and inhibit its activity.

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Published in:The Journal of cell biology 2000-09, Vol.150 (6), p.F117-F119
Main Author: Zigmond, Sally H.
Format: Article
Language:English
Subjects:
Actins
Actins - metabolism
Cell Physiological Phenomena
Cells
Cellular biology
Comment
Lymphocytes
Molecules
Neurons
Nucleation
Physiological regulation
Polymerization
Polymers
Polymers - metabolism
Profilins
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Receptors
Wiskott Aldrich syndrome
Wiskott-Aldrich Syndrome Protein
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description To investigate which region of the NH2 terminus is required for inhibition, different domains were expressed and examined for their ability to bind and inhibit the activity of the VCA fragment. NH2-terminal fragments that include the GBD bind VCA and inhibit its activity.
doi_str_mv 10.1083/jcb.150.6.F117
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source Alma/SFX Local Collection
subjects Actins
Actins - metabolism
Cell Physiological Phenomena
Cells
Cellular biology
Comment
Lymphocytes
Molecules
Neurons
Nucleation
Physiological regulation
Polymerization
Polymers
Polymers - metabolism
Profilins
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Receptors
Wiskott Aldrich syndrome
Wiskott-Aldrich Syndrome Protein
title How WASP Regulates Actin Polymerization
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