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Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer’s disease
OBJECTIVE Functional activation studies of semantic processing in healthy adults have yielded conflicting results. The purpose was to evaluate the relative role of the brain regions implicated in semantic processing with converging evidence from imaging studies of patients with impaired semantic pro...
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Published in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1997-08, Vol.63 (2), p.152-158 |
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description | OBJECTIVE Functional activation studies of semantic processing in healthy adults have yielded conflicting results. The purpose was to evaluate the relative role of the brain regions implicated in semantic processing with converging evidence from imaging studies of patients with impaired semantic processing. METHODS Semantic memory was assessed in patients with Alzheimer’s disease using two measures, and these performance patterns were related to profiles of reduced cerebral functioning obtained with high resolution single photon emission computed tomography (SPECT). Patients with frontotemporal degeneration were similarly evaluated as a control group. RESULTS Reduced relative cerebral perfusion was seen in parietal and posterior temporal brain regions of patients with Alzheimer’s disease but not patients with frontotemporal degeneration. Impairments on semantically guided category membership decision tasks were also seen in patients with Alzheimer’s disease but not those with frontotemporal degeneration. Performance on the semantic measures correlated with relative cerebral perfusion in inferior parietal and superior temporal regions of the left hemisphere only in Alzheimer’s disease. Relative perfusion was significantly lower in these regions in patients with Alzheimer’s disease with semantic difficulty compared with patients with Alzheimer’s disease with relatively preserved semantic processing. CONCLUSION These findings provide converging evidence to support the contribution of superior temporal and inferior parietal regions of the left hemisphere to semantic processing. |
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The purpose was to evaluate the relative role of the brain regions implicated in semantic processing with converging evidence from imaging studies of patients with impaired semantic processing. METHODS Semantic memory was assessed in patients with Alzheimer’s disease using two measures, and these performance patterns were related to profiles of reduced cerebral functioning obtained with high resolution single photon emission computed tomography (SPECT). Patients with frontotemporal degeneration were similarly evaluated as a control group. RESULTS Reduced relative cerebral perfusion was seen in parietal and posterior temporal brain regions of patients with Alzheimer’s disease but not patients with frontotemporal degeneration. Impairments on semantically guided category membership decision tasks were also seen in patients with Alzheimer’s disease but not those with frontotemporal degeneration. Performance on the semantic measures correlated with relative cerebral perfusion in inferior parietal and superior temporal regions of the left hemisphere only in Alzheimer’s disease. Relative perfusion was significantly lower in these regions in patients with Alzheimer’s disease with semantic difficulty compared with patients with Alzheimer’s disease with relatively preserved semantic processing. CONCLUSION These findings provide converging evidence to support the contribution of superior temporal and inferior parietal regions of the left hemisphere to semantic processing.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.63.2.152</identifier><identifier>PMID: 9285450</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Biological and medical sciences ; cortical ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Disease ; Education ; Female ; Frontal Lobe - diagnostic imaging ; Frontal Lobe - physiopathology ; Functional Laterality ; Humans ; Male ; Medical imaging ; Medical sciences ; Memory ; Memory Disorders - diagnosis ; Neuroimaging ; Neurology ; Occipital Lobe - diagnostic imaging ; Occipital Lobe - physiopathology ; Parietal Lobe - diagnostic imaging ; Parietal Lobe - physiopathology ; Patients ; Radionuclide Imaging ; semantic processing ; Semantics ; Temporal Lobe - diagnostic imaging ; Temporal Lobe - physiopathology ; Tomography</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1997-08, Vol.63 (2), p.152-158</ispartof><rights>Journal of Neurology, Neurosurgery, and Psychiatry</rights><rights>1997 INIST-CNRS</rights><rights>Copyright: 1997 Journal of Neurology, Neurosurgery, and Psychiatry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b576t-5130f3845935d9c60cabb019cf54f495b4b84e3aede85e0e8c042e9486cad6c23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169652/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169652/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,309,310,314,727,780,784,789,790,885,23930,23931,25140,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2809326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9285450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grossman, Murray</creatorcontrib><creatorcontrib>Payer, Franz</creatorcontrib><creatorcontrib>Onishi, Kris</creatorcontrib><creatorcontrib>White-Devine, Tammy</creatorcontrib><creatorcontrib>Morrison, Donald</creatorcontrib><creatorcontrib>D’Esposito, Mark</creatorcontrib><creatorcontrib>Robinson, Keith</creatorcontrib><creatorcontrib>Alavi, Abass</creatorcontrib><title>Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer’s disease</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>OBJECTIVE Functional activation studies of semantic processing in healthy adults have yielded conflicting results. The purpose was to evaluate the relative role of the brain regions implicated in semantic processing with converging evidence from imaging studies of patients with impaired semantic processing. METHODS Semantic memory was assessed in patients with Alzheimer’s disease using two measures, and these performance patterns were related to profiles of reduced cerebral functioning obtained with high resolution single photon emission computed tomography (SPECT). Patients with frontotemporal degeneration were similarly evaluated as a control group. RESULTS Reduced relative cerebral perfusion was seen in parietal and posterior temporal brain regions of patients with Alzheimer’s disease but not patients with frontotemporal degeneration. Impairments on semantically guided category membership decision tasks were also seen in patients with Alzheimer’s disease but not those with frontotemporal degeneration. Performance on the semantic measures correlated with relative cerebral perfusion in inferior parietal and superior temporal regions of the left hemisphere only in Alzheimer’s disease. Relative perfusion was significantly lower in these regions in patients with Alzheimer’s disease with semantic difficulty compared with patients with Alzheimer’s disease with relatively preserved semantic processing. CONCLUSION These findings provide converging evidence to support the contribution of superior temporal and inferior parietal regions of the left hemisphere to semantic processing.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>cortical</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>Disease</subject><subject>Education</subject><subject>Female</subject><subject>Frontal Lobe - diagnostic imaging</subject><subject>Frontal Lobe - physiopathology</subject><subject>Functional Laterality</subject><subject>Humans</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Memory Disorders - diagnosis</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Occipital Lobe - diagnostic imaging</subject><subject>Occipital Lobe - physiopathology</subject><subject>Parietal Lobe - diagnostic imaging</subject><subject>Parietal Lobe - physiopathology</subject><subject>Patients</subject><subject>Radionuclide Imaging</subject><subject>semantic processing</subject><subject>Semantics</subject><subject>Temporal Lobe - diagnostic imaging</subject><subject>Temporal Lobe - physiopathology</subject><subject>Tomography</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkUuv0zAQhSMEupQLS5ZIlkCITYofsRNvrnSpeKoCFjy6sxxn0rokdvEkCFjxN_h7_BJSWpXHBm9G8vl05oxOlt1mdM6YUA-3IezmSsz5nEl-JZuxQlW5EHR1NZtRynkuqKTXsxuIW7p_lT7LzjSvZCHpLOsWMeCQrA8DkhjIsAHiIEGdbEdqix5JGxNB6G0YvCO7FB0g-rAmbYo9CTCm6Hu73v_gMDYeJp-WXHZfN-B7SD--fUfSeASLcDO71toO4dZxnmdvnzx-s3iWL189fb64XOa1LNWQSyZoK6pCaiEb7RR1tq4p066VRVtoWRd1VYCw0EAlgULlaMFBF5VytlGOi_Ps4uC7G-seGgdhurAzuzQFTV9MtN78rQS_Mev4yXCmtJJ7g_tHgxQ_joCD6T066DobII5oSs2l1kxM4N1_wG0cU5iOM6ysmGSUiWKi8gPlUkRM0J6iMGr2JZp9iUYJww37tf7On_lP9LG1Sb931C0627XJBufxhPGKasHV77UeB_h8km36YFQpSmlevluY1fJF9fp9uTKPJv7Bga_77X8S_gTU0MUn</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Grossman, Murray</creator><creator>Payer, Franz</creator><creator>Onishi, Kris</creator><creator>White-Devine, Tammy</creator><creator>Morrison, Donald</creator><creator>D’Esposito, Mark</creator><creator>Robinson, Keith</creator><creator>Alavi, Abass</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19970801</creationdate><title>Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer’s disease</title><author>Grossman, Murray ; Payer, Franz ; Onishi, Kris ; White-Devine, Tammy ; Morrison, Donald ; D’Esposito, Mark ; Robinson, Keith ; Alavi, Abass</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b576t-5130f3845935d9c60cabb019cf54f495b4b84e3aede85e0e8c042e9486cad6c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aged</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>cortical</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia</topic><topic>Disease</topic><topic>Education</topic><topic>Female</topic><topic>Frontal Lobe - diagnostic imaging</topic><topic>Frontal Lobe - physiopathology</topic><topic>Functional Laterality</topic><topic>Humans</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Memory Disorders - diagnosis</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Occipital Lobe - diagnostic imaging</topic><topic>Occipital Lobe - physiopathology</topic><topic>Parietal Lobe - diagnostic imaging</topic><topic>Parietal Lobe - physiopathology</topic><topic>Patients</topic><topic>Radionuclide Imaging</topic><topic>semantic processing</topic><topic>Semantics</topic><topic>Temporal Lobe - diagnostic imaging</topic><topic>Temporal Lobe - physiopathology</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grossman, Murray</creatorcontrib><creatorcontrib>Payer, Franz</creatorcontrib><creatorcontrib>Onishi, Kris</creatorcontrib><creatorcontrib>White-Devine, Tammy</creatorcontrib><creatorcontrib>Morrison, Donald</creatorcontrib><creatorcontrib>D’Esposito, Mark</creatorcontrib><creatorcontrib>Robinson, Keith</creatorcontrib><creatorcontrib>Alavi, Abass</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grossman, Murray</au><au>Payer, Franz</au><au>Onishi, Kris</au><au>White-Devine, Tammy</au><au>Morrison, Donald</au><au>D’Esposito, Mark</au><au>Robinson, Keith</au><au>Alavi, Abass</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer’s disease</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>63</volume><issue>2</issue><spage>152</spage><epage>158</epage><pages>152-158</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>OBJECTIVE Functional activation studies of semantic processing in healthy adults have yielded conflicting results. The purpose was to evaluate the relative role of the brain regions implicated in semantic processing with converging evidence from imaging studies of patients with impaired semantic processing. METHODS Semantic memory was assessed in patients with Alzheimer’s disease using two measures, and these performance patterns were related to profiles of reduced cerebral functioning obtained with high resolution single photon emission computed tomography (SPECT). Patients with frontotemporal degeneration were similarly evaluated as a control group. RESULTS Reduced relative cerebral perfusion was seen in parietal and posterior temporal brain regions of patients with Alzheimer’s disease but not patients with frontotemporal degeneration. Impairments on semantically guided category membership decision tasks were also seen in patients with Alzheimer’s disease but not those with frontotemporal degeneration. Performance on the semantic measures correlated with relative cerebral perfusion in inferior parietal and superior temporal regions of the left hemisphere only in Alzheimer’s disease. Relative perfusion was significantly lower in these regions in patients with Alzheimer’s disease with semantic difficulty compared with patients with Alzheimer’s disease with relatively preserved semantic processing. CONCLUSION These findings provide converging evidence to support the contribution of superior temporal and inferior parietal regions of the left hemisphere to semantic processing.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>9285450</pmid><doi>10.1136/jnnp.63.2.152</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Alzheimer's disease Biological and medical sciences cortical Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Disease Education Female Frontal Lobe - diagnostic imaging Frontal Lobe - physiopathology Functional Laterality Humans Male Medical imaging Medical sciences Memory Memory Disorders - diagnosis Neuroimaging Neurology Occipital Lobe - diagnostic imaging Occipital Lobe - physiopathology Parietal Lobe - diagnostic imaging Parietal Lobe - physiopathology Patients Radionuclide Imaging semantic processing Semantics Temporal Lobe - diagnostic imaging Temporal Lobe - physiopathology Tomography |
title | Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer’s disease |
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