When Wnts Antagonize Wnts

Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that "noncanonical" Wnt signaling inhibits the "canonical" Wnt/β-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wn...

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Bibliographic Details
Published in:The Journal of cell biology 2003-09, Vol.162 (5), p.753-755
Main Authors: Weidinger, Gilbert, Moon, Randall T.
Format: Article
Language:English
Subjects:
Animal genetics
Animals
beta Catenin
Cell division
Cell lines
Cells
Chondrocytes
Chondrogenesis
Comment
Cytoskeletal Proteins - metabolism
Embryos
Gene expression regulation
Limb buds
Mice
Morphogenesis - physiology
Natural satellites
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Signal Transduction - physiology
Trans-Activators - metabolism
Vertebrates
Wnt Proteins
Zebrafish - embryology
Zebrafish Proteins
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Summary:Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that "noncanonical" Wnt signaling inhibits the "canonical" Wnt/β-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of β-catenin, whereas Topol et al. (2003) report that chondrogenesis in the distal mouse limb bud depends on inhibition of Wnt/β-catenin signaling by a paralogue of Wnt-5. These studies present the first genetic confirmation of the previous hypothesis that vertebrate Wnt signaling pathways can act in an antagonistic manner.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.200307181