Sorting It out: AP-2 and Alternate Clathrin Adaptors in Endocytic Cargo Selection

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly re...

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Bibliographic Details
Published in:The Journal of cell biology 2003-10, Vol.163 (2), p.203-208
Main Author: Traub, Linton M.
Format: Article
Language:English
Subjects:
Adaptor Protein Complex 2 - metabolism
Animals
Appendages
Cell Membrane - metabolism
Cell membranes
Cells
Clathrin - metabolism
Clathrin-Coated Vesicles - metabolism
Endocytosis
Endocytosis - physiology
Enzymes
Freight
Humans
Internalization
Mini-Review
Mini-Reviews
Models, Biological
Molecular biology
Molecules
Protein Binding
Protein Transport - physiology
Pulmonary tuberculosis
Receptors
Signal Transduction
Vesicular transport adaptor proteins
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Summary:The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.200309175