Allogeneic tumor rejection induced by the intravenous injection of Lyt-2+ cytolytic T lymphocyte clones

The in vivo activity of murine Lyt-2+ cytolytic T lymphocyte clones was assessed in a tumor allograft model system. Mice that had been sublethally irradiated 16 h previously were injected intraperitoneally with 131I-IUdR-labeled tumor cells. Simultaneously, various doses of four cytolytic T cell clo...

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Bibliographic Details
Published in:The Journal of experimental medicine 1982-10, Vol.156 (4), p.1280-1285
Main Authors: Engers, H D, Glasebrook, A L, Sorenson, G D
Format: Article
Language:English
Subjects:
Animals
Antigens, Ly
Clone Cells
Graft Rejection
Mice
Neoplasms, Experimental - immunology
T-Lymphocytes, Cytotoxic - immunology
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Summary:The in vivo activity of murine Lyt-2+ cytolytic T lymphocyte clones was assessed in a tumor allograft model system. Mice that had been sublethally irradiated 16 h previously were injected intraperitoneally with 131I-IUdR-labeled tumor cells. Simultaneously, various doses of four cytolytic T cell clones were injected intravenously and the mice monitored for tumor cell elimination by whole-body counting tecniques. These four clones had been selected on the basis of their ability to proliferate in response to alloantigens in the absence of added T cell growth factor(s). With two of the four clones tested, rapid elimination of tumor cells within the peritoneal cavity was observed, as early as 48 h after intravenous injection of the cloned T cells.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.156.4.1280