Ia antigens in rat kidney, with special reference to their expression in tubular epithelium

The distribution of Ia antigens in rat kidneys has been investigated by an immunoperoxidase technique, using monoclonal antibodies directed at framework determinants on molecules equivalent to gene products of the I-A and I-E/C regions of the mouse major histocompatibility complex (MHC). Antigens ma...

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Bibliographic Details
Published in:The Journal of experimental medicine 1983-06, Vol.157 (6), p.2097-2109
Main Authors: Mayrhofer, G, Schon-Hegrad, M A
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - immunology
Epithelium - immunology
Epithelium - ultrastructure
Female
Genes, MHC Class II
Histocompatibility Antigens Class II - analysis
Histocytochemistry
Immunoenzyme Techniques
Kidney - immunology
Kidney Glomerulus - immunology
Kidney Tubules - immunology
Male
Rats
Species Specificity
Tissue Distribution
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Summary:The distribution of Ia antigens in rat kidneys has been investigated by an immunoperoxidase technique, using monoclonal antibodies directed at framework determinants on molecules equivalent to gene products of the I-A and I-E/C regions of the mouse major histocompatibility complex (MHC). Antigens mapping to both loci were detected in proximal convoluted tubule epithelium and on scattered dendritic cells in the interstitial connective tissues, glomeruli, and mucosa of the renal pelvis. All other structures were negative. Genetic studies indicate that the levels of expression of Ia molecules from both genetic loci are controlled by non-MHC genes in epithelium, but not on lymphocytes. The subcellular distribution of Ia molecules has been investigated in tubular epithelium and is discussed in relation to their possible functions in epithelia.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.157.6.2097