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Increased Melatonin and Delayed Offset in Menopausal Depression: Role of Years Past Menopause, Follicle-Stimulating Hormone, Sleep End Time, and Body Mass Index
Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized. Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal con...
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| Published in: | The journal of clinical endocrinology and metabolism 2008-01, Vol.93 (1), p.54-60 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Parry, Barbara L. Meliska, Charles J. Sorenson, Diane L. López, Ana M. Martínez, Luis F. Nowakowski, Sara Hauger, Richard L. Elliott, Jeffrey A. |
| description | Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized.
Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controls women (NC).
Design: We measured plasma melatonin every 30 min from 1800–1000 h in dim light ( |
| doi_str_mv | 10.1210/jc.2006-2853 |
| format | article |
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Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controls women (NC).
Design: We measured plasma melatonin every 30 min from 1800–1000 h in dim light (<30 lux) or dark, serum gonadotropins and steroids (1800 and 0600 h), and mood (Hamilton and Beck depression ratings).
Setting: The study was conducted at a university hospital.
Participants and Setting: Twenty-nine (18 NC, 11 DP) peri- or postmenopausal women participated.
Main Outcome Measures: We measured plasma melatonin (onset, offset, synthesis offset, duration, peak concentration, and area under the curve) and mood.
Results: Multi- and univariate analyses of covariance showed that melatonin offset time was delayed (P = 0.045) and plasma melatonin was elevated in DP compared with NC (P = 0.044) across time intervals. Multiple regression analyses showed that years past menopause predicted melatonin duration and that melatonin duration, body mass index, years past menopause, FSH level, and sleep end time were significant predictors of baseline Hamilton (P = 0.0003) and Beck (P = 0.00004) depression scores.
Conclusions: Increased melatonin secretion that is phase delayed into the morning characterized menopausal DP vs. NC. Years past menopause, FSH, sleep end time, and body mass index may modulate effects of altered melatonin secretion in menopausal depression.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2006-2853</identifier><identifier>PMID: 18042653</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Biological and medical sciences ; Body Mass Index ; Circadian Rhythm - physiology ; Depressive Disorder - blood ; Endocrinopathies ; Estradiol - blood ; Feeding. Feeding behavior ; Female ; Follicle Stimulating Hormone - blood ; Fundamental and applied biological sciences. Psychology ; Humans ; Luteinizing Hormone - blood ; Medical sciences ; Melatonin - blood ; Menopause - blood ; Middle Aged ; Original ; Polysomnography ; Progesterone - blood ; Sleep - physiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2008-01, Vol.93 (1), p.54-60</ispartof><rights>Copyright © 2008 by The Endocrine Society</rights><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008 by The Endocrine Society 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5015-9230be73c2a7ef234e82f79e51f17a059f1f57daa3da53a586b48621e1e2c1463</citedby><cites>FETCH-LOGICAL-c5015-9230be73c2a7ef234e82f79e51f17a059f1f57daa3da53a586b48621e1e2c1463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19981389$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18042653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parry, Barbara L.</creatorcontrib><creatorcontrib>Meliska, Charles J.</creatorcontrib><creatorcontrib>Sorenson, Diane L.</creatorcontrib><creatorcontrib>López, Ana M.</creatorcontrib><creatorcontrib>Martínez, Luis F.</creatorcontrib><creatorcontrib>Nowakowski, Sara</creatorcontrib><creatorcontrib>Hauger, Richard L.</creatorcontrib><creatorcontrib>Elliott, Jeffrey A.</creatorcontrib><title>Increased Melatonin and Delayed Offset in Menopausal Depression: Role of Years Past Menopause, Follicle-Stimulating Hormone, Sleep End Time, and Body Mass Index</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized.
Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controls women (NC).
Design: We measured plasma melatonin every 30 min from 1800–1000 h in dim light (<30 lux) or dark, serum gonadotropins and steroids (1800 and 0600 h), and mood (Hamilton and Beck depression ratings).
Setting: The study was conducted at a university hospital.
Participants and Setting: Twenty-nine (18 NC, 11 DP) peri- or postmenopausal women participated.
Main Outcome Measures: We measured plasma melatonin (onset, offset, synthesis offset, duration, peak concentration, and area under the curve) and mood.
Results: Multi- and univariate analyses of covariance showed that melatonin offset time was delayed (P = 0.045) and plasma melatonin was elevated in DP compared with NC (P = 0.044) across time intervals. Multiple regression analyses showed that years past menopause predicted melatonin duration and that melatonin duration, body mass index, years past menopause, FSH level, and sleep end time were significant predictors of baseline Hamilton (P = 0.0003) and Beck (P = 0.00004) depression scores.
Conclusions: Increased melatonin secretion that is phase delayed into the morning characterized menopausal DP vs. NC. Years past menopause, FSH, sleep end time, and body mass index may modulate effects of altered melatonin secretion in menopausal depression.</description><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Circadian Rhythm - physiology</subject><subject>Depressive Disorder - blood</subject><subject>Endocrinopathies</subject><subject>Estradiol - blood</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Melatonin - blood</subject><subject>Menopause - blood</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Polysomnography</subject><subject>Progesterone - blood</subject><subject>Sleep - physiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNptkU1v1DAQhiMEokvhxhn5Aqem-CPOBwckKC1dqasiWiQ4WbPOpOvFsRc7oey_4afiaFctSFgaWTPzzLwjvVn2nNFjxhl9vdbHnNIy57UUD7IZawqZV6ypHmYzSjnLm4p_PciexLimlBWFFI-zA1bTgpdSzLLfc6cDQsSWLNDC4J1xBFxLPqRsm6qXXRdxIKm6QOc3MEawqbkJGKPx7g357C0S35FvCCGSTxCHOxKPyJm31miL-dVg-jEJGHdDzn3ovUvdK4u4IadJ7tr0KZ-E3_t2SxYQI5m7Fn89zR51YCM-2_-H2Zez0-uT8_zi8uP85N1FriVlMm-4oEushOZQYcdFgTXvqgYl61gFVDYd62TVAogWpABZl8uiLjlDhlyzohSH2dvd3s247LHV6IYAVm2C6SFslQej_u04s1I3_qfirKGVmBa82i8I_seIcVC9iRqtBYd-jKqirJaST-DRDtTBxxiwuxNhVE2WqrVWk6VqsjThL_4-7B7ee5iAl3sAogbbBXDaxHuuaWom6iZxxY679XbAEL_b8RaDWiHYYaVoekVZ1XlSrilLWZ6CyTQmdmPoWq-DcTvv1dqPwSVH_n_1H4Lmy90</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Parry, Barbara L.</creator><creator>Meliska, Charles J.</creator><creator>Sorenson, Diane L.</creator><creator>López, Ana M.</creator><creator>Martínez, Luis F.</creator><creator>Nowakowski, Sara</creator><creator>Hauger, Richard L.</creator><creator>Elliott, Jeffrey A.</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><general>The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200801</creationdate><title>Increased Melatonin and Delayed Offset in Menopausal Depression: Role of Years Past Menopause, Follicle-Stimulating Hormone, Sleep End Time, and Body Mass Index</title><author>Parry, Barbara L. ; Meliska, Charles J. ; Sorenson, Diane L. ; López, Ana M. ; Martínez, Luis F. ; Nowakowski, Sara ; Hauger, Richard L. ; Elliott, Jeffrey A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5015-9230be73c2a7ef234e82f79e51f17a059f1f57daa3da53a586b48621e1e2c1463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Circadian Rhythm - physiology</topic><topic>Depressive Disorder - blood</topic><topic>Endocrinopathies</topic><topic>Estradiol - blood</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Melatonin - blood</topic><topic>Menopause - blood</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Polysomnography</topic><topic>Progesterone - blood</topic><topic>Sleep - physiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parry, Barbara L.</creatorcontrib><creatorcontrib>Meliska, Charles J.</creatorcontrib><creatorcontrib>Sorenson, Diane L.</creatorcontrib><creatorcontrib>López, Ana M.</creatorcontrib><creatorcontrib>Martínez, Luis F.</creatorcontrib><creatorcontrib>Nowakowski, Sara</creatorcontrib><creatorcontrib>Hauger, Richard L.</creatorcontrib><creatorcontrib>Elliott, Jeffrey A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parry, Barbara L.</au><au>Meliska, Charles J.</au><au>Sorenson, Diane L.</au><au>López, Ana M.</au><au>Martínez, Luis F.</au><au>Nowakowski, Sara</au><au>Hauger, Richard L.</au><au>Elliott, Jeffrey A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Melatonin and Delayed Offset in Menopausal Depression: Role of Years Past Menopause, Follicle-Stimulating Hormone, Sleep End Time, and Body Mass Index</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2008-01</date><risdate>2008</risdate><volume>93</volume><issue>1</issue><spage>54</spage><epage>60</epage><pages>54-60</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized.
Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controls women (NC).
Design: We measured plasma melatonin every 30 min from 1800–1000 h in dim light (<30 lux) or dark, serum gonadotropins and steroids (1800 and 0600 h), and mood (Hamilton and Beck depression ratings).
Setting: The study was conducted at a university hospital.
Participants and Setting: Twenty-nine (18 NC, 11 DP) peri- or postmenopausal women participated.
Main Outcome Measures: We measured plasma melatonin (onset, offset, synthesis offset, duration, peak concentration, and area under the curve) and mood.
Results: Multi- and univariate analyses of covariance showed that melatonin offset time was delayed (P = 0.045) and plasma melatonin was elevated in DP compared with NC (P = 0.044) across time intervals. Multiple regression analyses showed that years past menopause predicted melatonin duration and that melatonin duration, body mass index, years past menopause, FSH level, and sleep end time were significant predictors of baseline Hamilton (P = 0.0003) and Beck (P = 0.00004) depression scores.
Conclusions: Increased melatonin secretion that is phase delayed into the morning characterized menopausal DP vs. NC. Years past menopause, FSH, sleep end time, and body mass index may modulate effects of altered melatonin secretion in menopausal depression.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>18042653</pmid><doi>10.1210/jc.2006-2853</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Online |
| subjects | Biological and medical sciences Body Mass Index Circadian Rhythm - physiology Depressive Disorder - blood Endocrinopathies Estradiol - blood Feeding. Feeding behavior Female Follicle Stimulating Hormone - blood Fundamental and applied biological sciences. Psychology Humans Luteinizing Hormone - blood Medical sciences Melatonin - blood Menopause - blood Middle Aged Original Polysomnography Progesterone - blood Sleep - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Increased Melatonin and Delayed Offset in Menopausal Depression: Role of Years Past Menopause, Follicle-Stimulating Hormone, Sleep End Time, and Body Mass Index |
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