The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow

To test whether the product of the bcl-2 proto-oncogene blocks clonal deletion of self-reactive B cells, we have generated transgenic mice carrying the bcl-2 gene and the immunoglobulin genes for the anti-erythrocyte 4C8 antibody. In these transgenic mice, clonal deletion of self-reactive immature B...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of experimental medicine 1993-10, Vol.178 (4), p.1247-1254
Main Authors: NISITANI, S, TSUBATA, T, MURAKAMI, M, OKAMOTO, M, HONJO, T
Format: Article
Language:English
Subjects:
Animals
Antigens, Ly - immunology
Apoptosis - immunology
Autoantibodies - genetics
Autoantibodies - immunology
Autoimmune Diseases - genetics
Autoimmune Diseases - immunology
Autoimmune Diseases - physiopathology
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Base Sequence
Biological and medical sciences
Bone Marrow - immunology
Bone Marrow Cells
Clone Cells
DNA
Erythrocytes - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes, Immunoglobulin
Immune Tolerance
Immunobiology
Immunological tolerance
Mice
Mice, Transgenic
Molecular Sequence Data
Peritoneal Cavity - cytology
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - physiology
Proto-Oncogene Proteins c-bcl-2
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To test whether the product of the bcl-2 proto-oncogene blocks clonal deletion of self-reactive B cells, we have generated transgenic mice carrying the bcl-2 gene and the immunoglobulin genes for the anti-erythrocyte 4C8 antibody. In these transgenic mice, clonal deletion of self-reactive immature B cells in the bone marrow was not inhibited in spite of expression of the bcl-2 gene. In contrast, self-antigen-induced clonal deletion of mature self-reactive Ly-1 B (B1) cells in the peritoneal cavity was inhibited in the transgenic mice. These results indicate that the mechanism for clonal deletion of immature self-reactive B cells in the bone marrow differs from that of mature self-reactive B cells in the periphery.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.178.4.1247