Short-lived and long-lived bone marrow plasma cells are derived from a novel precursor population

The contribution that long-lived bone marrow (BM) plasma cells (PCs) provide to enduring humoral immunity has been underscored by a number of recent studies. However, little is known about the immediate precursors that give rise to long-lived PCs in the BM of immune individuals. We have identified s...

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Bibliographic Details
Published in:The Journal of experimental medicine 2002-03, Vol.195 (6), p.737-745
Main Authors: O'Connor, Brian P, Cascalho, Marilia, Noelle, Randolph J
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Bone Marrow Cells - cytology
Bone Marrow Cells - immunology
Cell Differentiation
Cell Lineage - immunology
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - immunology
Immunophenotyping
Mice
Original
Plasma Cells - cytology
Plasma Cells - immunology
Time Factors
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Summary:The contribution that long-lived bone marrow (BM) plasma cells (PCs) provide to enduring humoral immunity has been underscored by a number of recent studies. However, little is known about the immediate precursors that give rise to long-lived PCs in the BM of immune individuals. We have identified subsets of antigen-experienced B cells within the immune BM that are precursors to PCs. These PC precursors arise in the BM 14 days after immunization and persist for greater than 9 months. Phenotypically distinct subsets of PC precursors give rise to short-lived or long-lived PCs. The differentiation of PC precursors to PCs occurs in the absence of antigen and requires cell division. The functional significance of these newly identified PC precursors in the persistence and quality of the humoral immune response is discussed.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20011626