Regulation of Nucleocytoplasmic Trafficking by Cell Adhesion Receptors and the Cytoskeleton

It has become widely accepted that adhesion receptors can either directly activate, or significantly modulate, many of the signaling cascades initiated by circulating growth factors. An interesting recent development is the realization that adhesion receptors and their cytoskeletal partners can regu...

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Bibliographic Details
Published in:The Journal of cell biology 2001-10, Vol.155 (2), p.187-191
Main Authors: Aplin, Andrew E., Juliano, R. L.
Format: Article
Language:English
Subjects:
Actins
Active Transport, Cell Nucleus - physiology
Animals
Cell Adhesion
Cell Adhesion Molecules - physiology
Cell Nucleus - metabolism
Cellular biology
Cytoskeleton - physiology
Embryonic cells
Epithelial cells
Gene expression regulation
Integrins
Mini-Reviews
Models, Biological
Molecules
Nuclear trafficking
Regulation
Signal Transduction
Transcription factors
Transcription Factors - metabolism
Transcriptional regulatory elements
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Summary:It has become widely accepted that adhesion receptors can either directly activate, or significantly modulate, many of the signaling cascades initiated by circulating growth factors. An interesting recent development is the realization that adhesion receptors and their cytoskeletal partners can regulate the trafficking of signaling proteins between the cytoplasm and nucleus. Cell adhesion molecule control of nucleocytoplasmic trafficking allows adhesion to influence many cell decisions, and highlights the diversity of nuclear import and export mechanisms.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.200107116