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Regulation of Nucleocytoplasmic Trafficking by Cell Adhesion Receptors and the Cytoskeleton

It has become widely accepted that adhesion receptors can either directly activate, or significantly modulate, many of the signaling cascades initiated by circulating growth factors. An interesting recent development is the realization that adhesion receptors and their cytoskeletal partners can regu...

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Published in:	The Journal of cell biology 2001-10, Vol.155 (2), p.187-191
Main Authors:	Aplin, Andrew E., Juliano, R. L.
Format:	Article
Language:	English
Subjects:	Actins Active Transport, Cell Nucleus - physiology Animals Cell Adhesion Cell Adhesion Molecules - physiology Cell Nucleus - metabolism Cellular biology Cytoskeleton - physiology Embryonic cells Epithelial cells Gene expression regulation Integrins Mini-Reviews Models, Biological Molecules Nuclear trafficking Regulation Signal Transduction Transcription factors Transcription Factors - metabolism Transcriptional regulatory elements
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container_title	The Journal of cell biology
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description	It has become widely accepted that adhesion receptors can either directly activate, or significantly modulate, many of the signaling cascades initiated by circulating growth factors. An interesting recent development is the realization that adhesion receptors and their cytoskeletal partners can regulate the trafficking of signaling proteins between the cytoplasm and nucleus. Cell adhesion molecule control of nucleocytoplasmic trafficking allows adhesion to influence many cell decisions, and highlights the diversity of nuclear import and export mechanisms.
doi_str_mv	10.1083/jcb.200107116
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subjects	Actins Active Transport, Cell Nucleus - physiology Animals Cell Adhesion Cell Adhesion Molecules - physiology Cell Nucleus - metabolism Cellular biology Cytoskeleton - physiology Embryonic cells Epithelial cells Gene expression regulation Integrins Mini-Reviews Models, Biological Molecules Nuclear trafficking Regulation Signal Transduction Transcription factors Transcription Factors - metabolism Transcriptional regulatory elements
title	Regulation of Nucleocytoplasmic Trafficking by Cell Adhesion Receptors and the Cytoskeleton
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