Soluble adhesion molecules in sera of patients with leprosy: levels of soluble intercellular adhesion molecule‐1 (sICAM‐1) rapidly decrease during multi‐drug therapy

The clinicopathological spectrum of leprosy is associated with an altered immunological reaction. The expression of adhesion molecules on endothelial cells directs the cellular traffic to sites of local skin and nerve inflammation. Soluble forms of adhesion molecules, which are released upon cytokin...

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Bibliographic Details
Published in:Clinical and experimental immunology 1996-07, Vol.105 (1), p.65-68
Main Authors: RIECKMA NN, P., SCHOLZE, G., WEICHSELBRAUN, I., GANAPATI, R., PRANGE, H. W.
Format: Article
Language:English
Subjects:
adhesion molecules
Adult
Bacterial diseases
Biological and medical sciences
Drug Therapy, Combination
E-Selectin - blood
Female
Human bacterial diseases
Humans
Infectious diseases
Intercellular Adhesion Molecule-1 - blood
Intercellular Adhesion Molecule-1 - drug effects
L-Selectin - blood
Leprosy
Leprosy - blood
Leprosy - drug therapy
Leprosy - immunology
Male
Medical sciences
Middle Aged
Mycobacterium leprae
Rapid Publications
sICAM‐1
Solubility
therapy
Tropical bacterial diseases
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Summary:The clinicopathological spectrum of leprosy is associated with an altered immunological reaction. The expression of adhesion molecules on endothelial cells directs the cellular traffic to sites of local skin and nerve inflammation. Soluble forms of adhesion molecules, which are released upon cytokine activation, can be detected in the circulation and may reflect ongoing tissue inflammation. We determined the serum levels of sICAM‐1, sE‐selectin and sL‐selectin in 74 patients with leprosy (tuberculoid form, n = 23; lepromatous form, n = 36; acute leprous reaction, n = 16) and 15 healthy age‐ and sex‐matched control donors. Patients with lepromatous leprosy had significantly higher levels of sICAM‐1 (564 ± 174 versus 450 ± 92 versus 334 ± 57 ng/ml) and E‐selectin (90 ± 31 versus 74 ± 29 versus 50 ± 10 ng/ml) than patients with tuberculoid leprosy and normal donors (P
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1996.d01-729.x