Molecular pathogenesis of emphysema

• Published in: The Journal of clinical investigation 2008-02, Vol.118 (2), p.394-402
• Main Authors: Taraseviciene-Stewart, Laimute, Voelkel, Norbert F
• Format: Article
• Language: English
• Subjects: alpha 1-Antitrypsin - metabolism; Animals; Biomedical research; Chronic obstructive pulmonary disease; Cigarettes; Diet therapy; Disease Models, Animal; Emphysema; Emphysema, Pulmonary; Guinea Pigs; Health aspects; Humans; Immunity, Innate; Lung diseases; Mice; Oxidative Stress; Pathogenesis; Peptide Hydrolases - metabolism; Personal; Prevention; Pulmonary Emphysema - etiology; Pulmonary Emphysema - genetics; Pulmonary Emphysema - metabolism; Rats; Risk factors; Smoking
• ISSN: 0021-9738; 1558-8238
• DOI: 10.1172/JCI31811

Emphysema is one manifestation of a group of chronic, obstructive, and frequently progressive destructive lung diseases. Cigarette smoking and air pollution are the main causes of emphysema in humans, and cigarette smoking causes emphysema in rodents. This review examines the concept of a homeostatically active lung structure maintenance program that, when attacked by proteases and oxidants, leads to the loss of alveolar septal cells and airspace enlargement. Inflammatory and noninflammatory mechanisms of disease pathogenesis, as well as the role of the innate and adaptive immune systems, are being explored in genetically altered animals and in exposure models of this disease. These recent scientific advances support a model whereby alveolar destruction resulting from a coalescence of mechanical forces, such as hyperinflation, and more recently recognized cellular and molecular events, including apoptosis, cellular senescence, and failed lung tissue repair, produces the clinically recognized syndrome of emphysema.