In Vivo Methods for the Assessment of Topical Drug Bioavailability

This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to...

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Bibliographic Details
Published in:Pharmaceutical research 2008-01, Vol.25 (1), p.87-103, Article 87
Main Authors: Herkenne, Christophe, Alberti, Ingo, Naik, Aarti, Kalia, Yogeshvar N., Mathy, François-Xavier, Préat, Véronique, Guy, Richard H.
Format: Article
Language:English
Subjects:
Administration, Topical
Algorithms
Bioavailability
Biochemistry
Biological and medical sciences
Biological Availability
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Drug therapy
Expert Review
General pharmacology
Humans
Medical Law
Medical procedures
Medical sciences
Microdialysis
Microscopy, Confocal
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - metabolism
Pharmaceutical technology. Pharmaceutical industry
Pharmacokinetics
Pharmacology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Skin - metabolism
Skin Absorption
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Summary:This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-007-9429-7