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In Vivo Methods for the Assessment of Topical Drug Bioavailability
This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to...
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| Published in: | Pharmaceutical research 2008-01, Vol.25 (1), p.87-103, Article 87 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c563t-31e86e3b5e64f1f88d99e358264b8c5dfbc2a277f4321b2f0a91ac3026aceb6d3 |
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| cites | cdi_FETCH-LOGICAL-c563t-31e86e3b5e64f1f88d99e358264b8c5dfbc2a277f4321b2f0a91ac3026aceb6d3 |
| container_end_page | 103 |
| container_issue | 1 |
| container_start_page | 87 |
| container_title | Pharmaceutical research |
| container_volume | 25 |
| creator | Herkenne, Christophe Alberti, Ingo Naik, Aarti Kalia, Yogeshvar N. Mathy, François-Xavier Préat, Véronique Guy, Richard H. |
| description | This paper reviews some current methods for the
in vivo
assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described. |
| doi_str_mv | 10.1007/s11095-007-9429-7 |
| format | article |
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in vivo
assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-007-9429-7</identifier><identifier>PMID: 17985216</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Administration, Topical ; Algorithms ; Bioavailability ; Biochemistry ; Biological and medical sciences ; Biological Availability ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Drug therapy ; Expert Review ; General pharmacology ; Humans ; Medical Law ; Medical procedures ; Medical sciences ; Microdialysis ; Microscopy, Confocal ; Pharmaceutical Preparations - administration & dosage ; Pharmaceutical Preparations - analysis ; Pharmaceutical Preparations - metabolism ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacokinetics ; Pharmacology ; Pharmacology. Drug treatments ; Pharmacology/Toxicology ; Pharmacy ; Skin - metabolism ; Skin Absorption</subject><ispartof>Pharmaceutical research, 2008-01, Vol.25 (1), p.87-103, Article 87</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><rights>2008 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-31e86e3b5e64f1f88d99e358264b8c5dfbc2a277f4321b2f0a91ac3026aceb6d3</citedby><cites>FETCH-LOGICAL-c563t-31e86e3b5e64f1f88d99e358264b8c5dfbc2a277f4321b2f0a91ac3026aceb6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20113684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17985216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herkenne, Christophe</creatorcontrib><creatorcontrib>Alberti, Ingo</creatorcontrib><creatorcontrib>Naik, Aarti</creatorcontrib><creatorcontrib>Kalia, Yogeshvar N.</creatorcontrib><creatorcontrib>Mathy, François-Xavier</creatorcontrib><creatorcontrib>Préat, Véronique</creatorcontrib><creatorcontrib>Guy, Richard H.</creatorcontrib><title>In Vivo Methods for the Assessment of Topical Drug Bioavailability</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><addtitle>Pharm Res</addtitle><description>This paper reviews some current methods for the
in vivo
assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.</description><subject>Administration, Topical</subject><subject>Algorithms</subject><subject>Bioavailability</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Drug therapy</subject><subject>Expert Review</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical Law</subject><subject>Medical procedures</subject><subject>Medical sciences</subject><subject>Microdialysis</subject><subject>Microscopy, Confocal</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Pharmacology. 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Pharmaceutical industry</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Skin - metabolism</topic><topic>Skin Absorption</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herkenne, Christophe</creatorcontrib><creatorcontrib>Alberti, Ingo</creatorcontrib><creatorcontrib>Naik, Aarti</creatorcontrib><creatorcontrib>Kalia, Yogeshvar N.</creatorcontrib><creatorcontrib>Mathy, François-Xavier</creatorcontrib><creatorcontrib>Préat, Véronique</creatorcontrib><creatorcontrib>Guy, Richard H.</creatorcontrib><collection>SpringerOpen (Open Access)</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herkenne, Christophe</au><au>Alberti, Ingo</au><au>Naik, Aarti</au><au>Kalia, Yogeshvar N.</au><au>Mathy, François-Xavier</au><au>Préat, Véronique</au><au>Guy, Richard H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Methods for the Assessment of Topical Drug Bioavailability</atitle><jtitle>Pharmaceutical research</jtitle><stitle>Pharm Res</stitle><addtitle>Pharm Res</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>25</volume><issue>1</issue><spage>87</spage><epage>103</epage><pages>87-103</pages><artnum>87</artnum><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>This paper reviews some current methods for the
in vivo
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| ispartof | Pharmaceutical research, 2008-01, Vol.25 (1), p.87-103, Article 87 |
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| language | eng |
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| subjects | Administration, Topical Algorithms Bioavailability Biochemistry Biological and medical sciences Biological Availability Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Drug therapy Expert Review General pharmacology Humans Medical Law Medical procedures Medical sciences Microdialysis Microscopy, Confocal Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - analysis Pharmaceutical Preparations - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Skin - metabolism Skin Absorption |
| title | In Vivo Methods for the Assessment of Topical Drug Bioavailability |
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