Micro-field evoked potentials recorded from the porcine sub-dural cortical surface utilizing a microelectrode array

A sub-dural surface microelectrode array designed to detect micro-field evoked potentials has been developed. The device is comprised of an array of 350-μm square gold contacts, with bidirectional spacing of 150μm, contained within a polyimide Kapton material. Cytotoxicity testing suggests that the...

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Bibliographic Details
Published in:Journal of neuroscience methods 2007-05, Vol.162 (1-2), p.155-161
Main Authors: Kitzmiller, Joseph P., Hansford, Derek J., Fortin, Linda D., Obrietan, Karl H., Bergdall, Valerie K., Beversdorf, David Q.
Format: Article
Language:English
Subjects:
Animals
Cell Survival
Cerebral Cortex - physiology
Cerebral Cortex - ultrastructure
Dominance, Cerebral
Evoked Potentials - physiology
Humans
Microelectrodes
Microscopy, Electron, Scanning
Multi-electrode arrays
Occipital Lobe - physiology
Polyimide electrodes
Sensitivity and Specificity
Surface microelectrodes
Swine
Visual cortex
Visual evoked potentials
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Summary:A sub-dural surface microelectrode array designed to detect micro-field evoked potentials has been developed. The device is comprised of an array of 350-μm square gold contacts, with bidirectional spacing of 150μm, contained within a polyimide Kapton material. Cytotoxicity testing suggests that the device is suitable for use with animal and human patients. Implementation of the device in animal studies revealed that reliable evoked potentials could be acquired. Further work will be needed to determine how these micro-field potentials, which demonstrate selectivity for one eye, relate to the distribution of the ocular dominance columns of the occipital cortex.
ISSN:0165-0270
1872-678X
DOI:10.1016/j.jneumeth.2007.01.004