Mycoplasma californicum mastitis in ewes as an experimental model for antibiotic treatment

A strain of Mycoplasma californicum successfully infected an experimentally inoculated ovine mammary gland causing a severe mastitis. The condition lasted for about 25 days, and resulted in atrophy and loss of milk production in the gland. Four experimentally infected ewes, treated over a 3-day peri...

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Bibliographic Details
Published in:Epidemiology and infection 1987-06, Vol.98 (3), p.369-378
Main Authors: Ball, H. J., Logan, E. F., Campbell, J. N.
Format: Article
Language:English
Subjects:
Animal bacterial diseases
Animals
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacterial diseases
Biological and medical sciences
Ewes
Female
Infections
Infectious diseases
Inoculation
Mammary glands
Mastitis
Mastitis - drug therapy
Mastitis - veterinary
Medical sciences
Milk - metabolism
Mycoplasma
Mycoplasma Infections - drug therapy
Mycoplasma Infections - veterinary
Sheep
Sheep Diseases - drug therapy
Ungulates
Veterinary medicine
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Summary:A strain of Mycoplasma californicum successfully infected an experimentally inoculated ovine mammary gland causing a severe mastitis. The condition lasted for about 25 days, and resulted in atrophy and loss of milk production in the gland. Four experimentally infected ewes, treated over a 3-day period with various regimes of the antibiotics oxytetracycline or tylosin during the acute stage of infection, successfully eliminated the infection. Two others similarly treated with combined intramammary and intramuscular tiamulin or with intramammary Bay Vp2674, did not eliminate the infection; but another ewe treated with intramuscular as well as intramammary Bay Vp2674, did resolve the infection. The two ewes that were unsuccessfully treated with antibiotics at the acute stage did respond to tylosin or oxytetracycline at a later stage of infection. Measurement of antibiotic concentrations demonstrated that the persistence of inhibitory levels in the milk varied between the antibiotics and were influenced by the extent of parenteral treatment.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268800062130