STITCH: interaction networks of chemicals and proteins

The knowledge about interactions between proteins and small molecules is essential for the understanding of molecular and cellular functions. However, information on such interactions is widely dispersed across numerous databases and the literature. To facilitate access to this data, STITCH ('s...

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Bibliographic Details
Published in:Nucleic acids research 2008-01, Vol.36 (suppl-1), p.D684-D688
Main Authors: Kuhn, Michael, von Mering, Christian, Campillos, Monica, Jensen, Lars Juhl, Bork, Peer
Format: Article
Language:English
Subjects:
Databases, Factual
Internet
Models, Chemical
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
User-Computer Interface
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Summary:The knowledge about interactions between proteins and small molecules is essential for the understanding of molecular and cellular functions. However, information on such interactions is widely dispersed across numerous databases and the literature. To facilitate access to this data, STITCH ('search tool for interactions of chemicals') integrates information about interactions from metabolic pathways, crystal structures, binding experiments and drug-target relationships. Inferred information from phenotypic effects, text mining and chemical structure similarity is used to predict relations between chemicals. STITCH further allows exploring the network of chemical relations, also in the context of associated binding proteins. Each proposed interaction can be traced back to the original data sources. Our database contains interaction information for over 68 000 different chemicals, including 2200 drugs, and connects them to 1.5 million genes across 373 genomes and their interactions contained in the STRING database. STITCH is available at http://stitch.embl.de/
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkm795