Gait analysis in a murine model of collagen-induced arthritis

Murine collagen-induced arthritis (CIA) has become a valuable animal model for elucidating pathogenic mechanisms and evaluating therapeutic effects for rheumatoid arthritis. Recent advances in digital imaging and computer technology have enabled gait analysis to develop into a powerful tool for obje...

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Bibliographic Details
Published in:Arthritis research & therapy 2007-01, Vol.9 (6), p.R123-R123, Article R123
Main Authors: Vincelette, Jon, Xu, Yifan, Zhang, Le-Ning, Schaefer, Caralee J, Vergona, Ronald, Sullivan, Mark E, Hampton, Thomas G, Wang, Yi-Xin Jim
Format: Article
Language:English
Subjects:
Animals
Arthritis, Experimental - complications
Arthritis, Experimental - physiopathology
Arthritis, Rheumatoid - physiopathology
Biomechanical Phenomena
Care and treatment
Diagnosis
Female
Gait
Gait - physiology
Health aspects
Humans
Lameness, Animal - etiology
Lameness, Animal - physiopathology
Medical equipment
Mice
Mice, Inbred DBA
Physiological apparatus
Rheumatoid arthritis
Time Factors
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Summary:Murine collagen-induced arthritis (CIA) has become a valuable animal model for elucidating pathogenic mechanisms and evaluating therapeutic effects for rheumatoid arthritis. Recent advances in digital imaging and computer technology have enabled gait analysis to develop into a powerful tool for objectively detecting functional deficits in human and animal models. The present study explored the use of non-invasive video-capture gait analysis in the evaluation of a murine CIA model. CIA was induced in 45 female DBA/1LacJ mice (8 to 10 weeks old) by immunization with lyophilized bovine articular type II collagen. Gait parameters were determined by ventral plane videography and were correlated to traditional arthritis clinical scores. Our results showed that increases in clinical scores that measure the severity of CIA corresponded to changes in multiple gait parameters that reflect both morphologic (increases in paw area) and functional (increase in stride frequency, decrease in stride length, hind-limb paw placement angle, as well as stride, stance, and braking times) deficits. Our work indicated that the non-invasive video-capture device may be used as a simple and objective data acquisition system for quantifying gait disturbances in CIA mice for the investigation of mechanisms and the evaluation of therapeutic agents.
ISSN:1478-6354
1478-6362
1478-6354
DOI:10.1186/ar2331