Epidermal growth factor receptor and oestrogen receptors in the non-malignant part of the cancerous breast

Fifty-one samples of non-malignant tissue from four mastectomies were analysed to assess oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) status across the cancerous breast. No significant relationship was found between the presence of EGFR and ER. Eighty-four per cent of these sa...

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Bibliographic Details
Published in:British journal of cancer 1989-11, Vol.60 (5), p.673-677
Main Authors: Barker, S, Panahy, C, Puddefoot, JR, Goode, AW, Vinson, GP
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Breast - analysis
Breast Neoplasms - metabolism
Cancer Research
Diseases of mother, fetus and pregnancy
Drug Resistance
Epidemiology
ErbB Receptors - analysis
experimental-oncology
Female
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Molecular Medicine
Oncology
Pregnancy. Fetus. Placenta
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
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Summary:Fifty-one samples of non-malignant tissue from four mastectomies were analysed to assess oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) status across the cancerous breast. No significant relationship was found between the presence of EGFR and ER. Eighty-four per cent of these samples were EGFR positive and 29% expressed both receptor types. EGFR and ER expression was not affected by histological sub-group. In contrast, analysis of 44 primary cancers showed, in agreement with the literature, a significant inverse relationship between the presence of ER and EGFR (Fisher's exact test P less than 0.002). The difference between malignant and non-malignant tissue appeared to result from the prevalence of co-expression of EGFR and ER in the non-malignant specimens. This suggests different regulation of receptor expression in malignant and non-malignant tissue.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1989.338