Response to foot-and-mouth disease vaccines in newborn calves. Influence of age, colostral antibodies and adjuvants

Oil-emulsified (OE) and aqueous (Aq) vaccines were prepared with the same batch of inactivated A24 8345 foot and mouth disease virus (FMDV). Calves born to vaccinated dams did not respond to the Aq vaccine 30 or 90 days post partum. When the OE vaccine was used on a similar group of calves, no respo...

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Bibliographic Details
Published in:Epidemiology and infection 1988-02, Vol.100 (1), p.135-144
Main Authors: Sadir, A. M., Schudel, A. A., Laporte, O., Braun, M., Margni, R. A.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Animals, Newborn - immunology
Antibodies
Antibodies, Viral - biosynthesis
Antibodies, Viral - immunology
Antigens
Aphthovirus - immunology
Biological and medical sciences
Calves
Cattle - immunology
Cattle Diseases - immunology
Colostrum - immunology
Dams
Foot and mouth disease
Foot-and-Mouth Disease - immunology
Foot-and-Mouth Disease - prevention & control
Fundamental and applied biological sciences. Psychology
Half lives
Immunity, Maternally-Acquired
Microbiology
Neutralizing antibodies
Vaccination
Vaccination - veterinary
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Veterinary medicine
Viral Vaccines - immunology
Virology
Viruses
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Summary:Oil-emulsified (OE) and aqueous (Aq) vaccines were prepared with the same batch of inactivated A24 8345 foot and mouth disease virus (FMDV). Calves born to vaccinated dams did not respond to the Aq vaccine 30 or 90 days post partum. When the OE vaccine was used on a similar group of calves, no responses were elicited up to 21 days post partum. However, calves 30 or more days old responded like adult cattle to the OE vaccine. When the OE vaccine was used in colostral antibody-free calves 3–30 days old, all animals showed good antibody responses but, in calves vaccinated 3 or 7 days post partum, antibodies were detectable only after a considerable period of time. Our results show that both passively acquired colostral antibodies and age are important in the response of very young calves to FMDV oil vaccines. From a practical point of view, in endemic areas where adult cattle are periodically vaccinated, vaccination of calves between 30 and 60 days post partum with OE vaccines would lead to high levels of herd protection.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268800065626