A community outbreak of group A beta haemolytic streptococci with transferable resistance to erythromycin

Erythromycin resistance amongst group A streptococci (GAS) in Great Britain is a relatively rare occurrence and outbreaks have been sporadically reported. Over an 8-month period in 1986 ten associated cases occurred in the town of Bridgwater in Somerset. Isolates were group A, type M4 and resistant...

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Bibliographic Details
Published in:Epidemiology and infection 1989-02, Vol.102 (1), p.85-91
Main Authors: Scott, R. J. D., Naidoo, J., Lightfoot, N. F., George, R. C.
Format: Article
Language:English
Subjects:
Action of physical and chemical agents on bacteria
Adult
Antibiotic resistance
Antibiotics
Bacteriology
Biological and medical sciences
Child
Child, Preschool
Conjugation, Genetic
Disease Outbreaks
Drug Resistance, Microbial - genetics
Elementary schools
England
Erythromycin - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Humans
Infant
Infections
Lincosamides
Male
Microbiology
Pharyngitis
Plasmids
Public health
Schools
Streptococcal Infections - epidemiology
Streptococcal Infections - microbiology
Streptococcus pyogenes
Streptococcus pyogenes - genetics
Streptococcus pyogenes - isolation & purification
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Summary:Erythromycin resistance amongst group A streptococci (GAS) in Great Britain is a relatively rare occurrence and outbreaks have been sporadically reported. Over an 8-month period in 1986 ten associated cases occurred in the town of Bridgwater in Somerset. Isolates were group A, type M4 and resistant to erythromycin (MIC 8 mg/l) but sensitive to lincomycin and clindamycin. Erythromycin resistance was transferable from all isolates to a group A recipient strain. No plasmid DNA could be detected in the original isolates or transconjugants.
ISSN:0950-2688
1469-4409
DOI:10.1017/S095026880002971X