Intradermal hepatitis B immunization with yeast-derived vaccine: serological response by sex and age

The efficacy and acceptability of yeast-derived recombinant hepatitis B vaccine given by the intradermal route was investigated in 221 health care volunteers. Two hundred and sixteen received a full course of three doses of vaccine. Only one subject was withdrawn because of a significant adverse rea...

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Bibliographic Details
Published in:Epidemiology and infection 1989-10, Vol.103 (2), p.387-394
Main Authors: Morris, C. A., Oliver, P. R., Reynolds, F., Selkon, J. B.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Antibodies
Biological and medical sciences
Dosage
Female
Fundamental and applied biological sciences. Psychology
Hepatitis B
Hepatitis B Antibodies - biosynthesis
Hepatitis B Vaccines
Hepatitis B virus - immunology
Humans
Immunity
Immunization
Injections, Intradermal
Male
Men
Microbiology
Middle Aged
Psoriasis
Retrospective Studies
Sex Factors
Vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - adverse effects
Vaccines, Synthetic - immunology
Viral Hepatitis Vaccines - administration & dosage
Viral Hepatitis Vaccines - adverse effects
Viral Hepatitis Vaccines - immunology
Virology
Volunteerism
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Summary:The efficacy and acceptability of yeast-derived recombinant hepatitis B vaccine given by the intradermal route was investigated in 221 health care volunteers. Two hundred and sixteen received a full course of three doses of vaccine. Only one subject was withdrawn because of a significant adverse reaction (psoriasis). The vaccine stimulated an antibody response in 81%. The response to the vaccine was better in women than in men (87% compared with 71%, p = 0·007) and in women below the age of 40 years compared with older women (94% compared with 76%, p = 0·01). For men the response showed a sequential decline with age for each decade (90% responders from age 29 or less, 72% aged 30—39 and 65% aged 40 or more, p = 0·04). Retrospective enquiry showed that over 90% had found the intradermal route acceptable and 59% would prefer vaccine by the intradermal route in preference to intramuscular notwithstanding local reactions. Although the seroconversion rate was of a high order in younger women the antibody titres were not high with only 9 of 215 recipients developing titres >1000 mIU/ml, a level which could be expected to ensure prolonged immunity. A fourth intradermal dose of vaccine given to 60 volunteers who had shown a low response (
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268800030740