The Peter Pan paradigm

Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally...

Full description

Saved in:
Bibliographic Details
Published in:Theoretical biology and medical modelling 2008-01, Vol.5 (1), p.1-1, Article 1
Main Authors: Cohen, J Craig, Larson, Janet E
Format: Article
Language:English
Subjects:
Cell Differentiation
Female
Fetal Development
Humans
Lung - embryology
Models, Biological
Organogenesis
Pregnancy
Premature Birth
Prenatal Exposure Delayed Effects - physiopathology
Review
Stem Cells - cytology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-b543t-99286631a9645a054ae42188111bbe36afd44b0c1a7620f3593242a3b6f9d6923
cites cdi_FETCH-LOGICAL-b543t-99286631a9645a054ae42188111bbe36afd44b0c1a7620f3593242a3b6f9d6923
container_end_page 1
container_issue 1
container_start_page 1
container_title Theoretical biology and medical modelling
container_volume 5
creator Cohen, J Craig
Larson, Janet E
description Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults, condemning the patient to utilize under-developed tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis."You may delay, but time will not" Benjamin Franklin, USA Founding Father.
doi_str_mv 10.1186/1742-4682-5-1
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2249573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A175144237</galeid><sourcerecordid>A175144237</sourcerecordid><originalsourceid>FETCH-LOGICAL-b543t-99286631a9645a054ae42188111bbe36afd44b0c1a7620f3593242a3b6f9d6923</originalsourceid><addsrcrecordid>eNp1kt9LwzAQx4Mobk4f9VEGguBDZy9J0-ZFHMMfg4FD53NI23SLtM1sWtH_3paOuaISSC65z33JfTmETsEdAQTsGnyKHcoC7HgO7KH-9r6_E_fQkbVvrou5z_kh6kEAAQbAfXS2WKnhXJWqGM5lPlzLQsZ6mR2jg0SmVp1szgF6vb9bTB6d2dPDdDKeOaFHSelwjgPGCEjOqCddj0pFMQQBAIShIkwmMaWhG4H0GXYT4nGCKZYkZAmPGcdkgG5a3XUVZiqOVF4WMhXrQmey-BJGatHN5HolluZDYEy555Na4LYVCLX5R6CbiUwmGl9E44vwBNQSl5s_FOa9UrYUmbaRSlOZK1NZ4bsEY1bvA3TRgkuZKqHzxNSKUQOLMfgeUIqJX1OjP6h6xSrTkclVouv3TsFVp6BmSvVZLmVlrZi-PHdZp2WjwlhbqGTbKbiimYdfvZ3v-vtDbwaAfAM-mqu8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70322670</pqid></control><display><type>article</type><title>The Peter Pan paradigm</title><source>PMC (PubMed Central)</source><creator>Cohen, J Craig ; Larson, Janet E</creator><creatorcontrib>Cohen, J Craig ; Larson, Janet E</creatorcontrib><description>Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults, condemning the patient to utilize under-developed tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis."You may delay, but time will not" Benjamin Franklin, USA Founding Father.</description><identifier>ISSN: 1742-4682</identifier><identifier>EISSN: 1742-4682</identifier><identifier>DOI: 10.1186/1742-4682-5-1</identifier><identifier>PMID: 18182112</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Cell Differentiation ; Female ; Fetal Development ; Humans ; Lung - embryology ; Models, Biological ; Organogenesis ; Pregnancy ; Premature Birth ; Prenatal Exposure Delayed Effects - physiopathology ; Review ; Stem Cells - cytology</subject><ispartof>Theoretical biology and medical modelling, 2008-01, Vol.5 (1), p.1-1, Article 1</ispartof><rights>COPYRIGHT 2008 BioMed Central Ltd.</rights><rights>Copyright © 2008 Cohen and Larson; licensee BioMed Central Ltd. 2008 Cohen and Larson; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b543t-99286631a9645a054ae42188111bbe36afd44b0c1a7620f3593242a3b6f9d6923</citedby><cites>FETCH-LOGICAL-b543t-99286631a9645a054ae42188111bbe36afd44b0c1a7620f3593242a3b6f9d6923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249573/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249573/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18182112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, J Craig</creatorcontrib><creatorcontrib>Larson, Janet E</creatorcontrib><title>The Peter Pan paradigm</title><title>Theoretical biology and medical modelling</title><addtitle>Theor Biol Med Model</addtitle><description>Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults, condemning the patient to utilize under-developed tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis."You may delay, but time will not" Benjamin Franklin, USA Founding Father.</description><subject>Cell Differentiation</subject><subject>Female</subject><subject>Fetal Development</subject><subject>Humans</subject><subject>Lung - embryology</subject><subject>Models, Biological</subject><subject>Organogenesis</subject><subject>Pregnancy</subject><subject>Premature Birth</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Review</subject><subject>Stem Cells - cytology</subject><issn>1742-4682</issn><issn>1742-4682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp1kt9LwzAQx4Mobk4f9VEGguBDZy9J0-ZFHMMfg4FD53NI23SLtM1sWtH_3paOuaISSC65z33JfTmETsEdAQTsGnyKHcoC7HgO7KH-9r6_E_fQkbVvrou5z_kh6kEAAQbAfXS2WKnhXJWqGM5lPlzLQsZ6mR2jg0SmVp1szgF6vb9bTB6d2dPDdDKeOaFHSelwjgPGCEjOqCddj0pFMQQBAIShIkwmMaWhG4H0GXYT4nGCKZYkZAmPGcdkgG5a3XUVZiqOVF4WMhXrQmey-BJGatHN5HolluZDYEy555Na4LYVCLX5R6CbiUwmGl9E44vwBNQSl5s_FOa9UrYUmbaRSlOZK1NZ4bsEY1bvA3TRgkuZKqHzxNSKUQOLMfgeUIqJX1OjP6h6xSrTkclVouv3TsFVp6BmSvVZLmVlrZi-PHdZp2WjwlhbqGTbKbiimYdfvZ3v-vtDbwaAfAM-mqu8</recordid><startdate>20080108</startdate><enddate>20080108</enddate><creator>Cohen, J Craig</creator><creator>Larson, Janet E</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080108</creationdate><title>The Peter Pan paradigm</title><author>Cohen, J Craig ; Larson, Janet E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b543t-99286631a9645a054ae42188111bbe36afd44b0c1a7620f3593242a3b6f9d6923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Cell Differentiation</topic><topic>Female</topic><topic>Fetal Development</topic><topic>Humans</topic><topic>Lung - embryology</topic><topic>Models, Biological</topic><topic>Organogenesis</topic><topic>Pregnancy</topic><topic>Premature Birth</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Review</topic><topic>Stem Cells - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, J Craig</creatorcontrib><creatorcontrib>Larson, Janet E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Science (Gale in Context)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Theoretical biology and medical modelling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, J Craig</au><au>Larson, Janet E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Peter Pan paradigm</atitle><jtitle>Theoretical biology and medical modelling</jtitle><addtitle>Theor Biol Med Model</addtitle><date>2008-01-08</date><risdate>2008</risdate><volume>5</volume><issue>1</issue><spage>1</spage><epage>1</epage><pages>1-1</pages><artnum>1</artnum><issn>1742-4682</issn><eissn>1742-4682</eissn><abstract>Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults, condemning the patient to utilize under-developed tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis."You may delay, but time will not" Benjamin Franklin, USA Founding Father.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>18182112</pmid><doi>10.1186/1742-4682-5-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1742-4682
ispartof Theoretical biology and medical modelling, 2008-01, Vol.5 (1), p.1-1, Article 1
issn 1742-4682
1742-4682
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2249573
source PMC (PubMed Central)
subjects Cell Differentiation
Female
Fetal Development
Humans
Lung - embryology
Models, Biological
Organogenesis
Pregnancy
Premature Birth
Prenatal Exposure Delayed Effects - physiopathology
Review
Stem Cells - cytology
title The Peter Pan paradigm
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T18%3A10%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Peter%20Pan%20paradigm&rft.jtitle=Theoretical%20biology%20and%20medical%20modelling&rft.au=Cohen,%20J%20Craig&rft.date=2008-01-08&rft.volume=5&rft.issue=1&rft.spage=1&rft.epage=1&rft.pages=1-1&rft.artnum=1&rft.issn=1742-4682&rft.eissn=1742-4682&rft_id=info:doi/10.1186/1742-4682-5-1&rft_dat=%3Cgale_pubme%3EA175144237%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b543t-99286631a9645a054ae42188111bbe36afd44b0c1a7620f3593242a3b6f9d6923%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=70322670&rft_id=info:pmid/18182112&rft_galeid=A175144237&rfr_iscdi=true