Crystal structure of the Yersinia type III secretion protein YscE

The plague‐causing bacterium Yersinia pestis utilizes a contact‐dependent (type III) secretion system (T3SS) to transport virulence factors from the bacterial cytosol directly into the interior of mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and th...

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Bibliographic Details
Published in:Protein science 2005-10, Vol.14 (10), p.2759-2763
Main Authors: Phan, Jason, Austin, Brian P., Waugh, David S.
Format: Article
Language:English
Subjects:
Animals
Bacterial Outer Membrane Proteins - chemistry
Bacterial Outer Membrane Proteins - metabolism
crystal structure
Crystallography, X-Ray
Dimerization
Phagocytosis - physiology
plague
Protein Structure Report
Protein Transport - physiology
Signal Transduction - physiology
type III secretion
Virulence Factors - metabolism
Yersinia pestis
Yersinia pestis - chemistry
Yersinia pestis - physiology
YscE
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Summary:The plague‐causing bacterium Yersinia pestis utilizes a contact‐dependent (type III) secretion system (T3SS) to transport virulence factors from the bacterial cytosol directly into the interior of mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. The type III secretion apparatus is composed of 20–25 different Yersinia secretion (Ysc) proteins. We report here the structure of YscE, the smallest Ysc protein, which is a dimer in solution. The probable mode of oligomerization is discussed.
ISSN:0961-8368
1469-896X
DOI:10.1110/ps.051706105