Distribution of Systemic Ciprofloxacin and Doxycycline to Gingiva and Gingival Crevicular Fluid

Background: Systemic fluoroquinolones and tetracyclines reach steady‐state levels in gingival crevicular fluid (GCF) that are several‐fold higher than their levels in serum. The mechanism by which this occurs is unclear, but gingival fibroblasts are known to accumulate these agents. Uptake by fibrob...

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Bibliographic Details
Published in:Journal of periodontology (1970) 2004-12, Vol.75 (12), p.1663-1667
Main Authors: Lavda, Maria, Clausnitzer, C. Esther, Walters, John D.
Format: Article
Language:English
Subjects:
Administration, Oral
Analysis of Variance
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - blood
Anti-Infective Agents - pharmacokinetics
Chromatography, High Pressure Liquid
Ciprofloxacin - administration & dosage
Ciprofloxacin - blood
Ciprofloxacin - pharmacokinetics
Connective tissue, gingival/analysis
Dentistry
Doxycycline - administration & dosage
Doxycycline - blood
Doxycycline - pharmacokinetics
fibroblasts
Fibroblasts - metabolism
fluoroquinolones
Fluoroquinolones - administration & dosage
Fluoroquinolones - blood
Fluoroquinolones - pharmacokinetics
Gingiva - cytology
Gingiva - metabolism
Gingival Crevicular Fluid - chemistry
Gingival Crevicular Fluid - metabolism
gingival crevicular fluid/analysis
Humans
serum/analysis
tetracyclines
Tetracyclines - administration & dosage
Tetracyclines - blood
Tetracyclines - pharmacology
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Summary:Background: Systemic fluoroquinolones and tetracyclines reach steady‐state levels in gingival crevicular fluid (GCF) that are several‐fold higher than their levels in serum. The mechanism by which this occurs is unclear, but gingival fibroblasts are known to accumulate these agents. Uptake by fibroblasts could enhance their distribution to gingiva. To test this hypothesis, steady‐state levels of these agents were assayed in serum, gingival connective tissue (GCT), and GCF. Methods: Healthy subjects who needed resective periodontal surgery participated in the study. Approximately 78 hours prior to the surgical appointment, each subject began a 3‐day regimen of ciprofloxacin or doxycycline. At the surgical appointment (scheduled approximately 6 hours after the last dose), samples of blood and GCT were collected. GCF samples were collected on paper strips and measured with an electronic device. Samples were extracted and analyzed by high performance liquid chromatography. Results: Mean ciprofloxacin levels in serum, GCT, and GCF were 0.40 µg/ml, 1.38 µg/g, and 1.66 µg/ml, respectively (P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2004.75.12.1663