Functional neural networks underlying response inhibition in adolescents and adults

This study provides the first description of neural network dynamics associated with response inhibition in healthy adolescents and adults. Functional and effective connectivity analyses of whole brain hemodynamic activity elicited during performance of a Go/No-Go task were used to identify function...

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Bibliographic Details
Published in:Behavioural brain research 2007-07, Vol.181 (1), p.12-22
Main Authors: Stevens, Michael C., Kiehl, Kent A., Pearlson, Godfrey D., Calhoun, Vince D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aging - physiology
Behavioral psychophysiology
Biological and medical sciences
Brain
Brain Mapping
Child
Choice Behavior - physiology
Development
Female
Fundamental and applied biological sciences. Psychology
Humans
Image Processing, Computer-Assisted - methods
Independent component analysis
Inhibition, Psychological
Magnetic Resonance Imaging - methods
Male
MRI
Nerve Net - blood supply
Nerve Net - physiology
Network
Neural Networks, Computer
Neuropsychological Tests
Oxygen - blood
Photic Stimulation
Principal Component Analysis
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reaction Time - physiology
Response inhibition
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Summary:This study provides the first description of neural network dynamics associated with response inhibition in healthy adolescents and adults. Functional and effective connectivity analyses of whole brain hemodynamic activity elicited during performance of a Go/No-Go task were used to identify functionally integrated neural networks and characterize their causal interactions. Three response inhibition circuits formed a hierarchical, inter-dependent system wherein thalamic modulation of input to premotor cortex by fronto-striatal regions led to response suppression. Adolescents differed from adults in the degree of network engagement, regional fronto-striatal-thalamic connectivity, and network dynamics. We identify and characterize several age-related differences in the function of neural circuits that are associated with behavioral performance changes across adolescent development.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2007.03.023