Short-Term Aerobic Exercise Training in Obese Humans with Type 2 Diabetes Mellitus Improves Whole-Body Insulin Sensitivity through Gains in Peripheral, not Hepatic Insulin Sensitivity

• Published in: The journal of clinical endocrinology and metabolism 2008-03, Vol.93 (3), p.771-778
• Main Authors: Winnick, Jason J., Sherman, W. Michael, Habash, Diane L., Stout, Michael B., Failla, Mark L., Belury, Martha A., Schuster, Dara P.
• Format: Article
• Language: English
• Subjects: Adult; Basal Metabolism; Biological and medical sciences; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Exercise; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Glucose - metabolism; Glucose Tolerance Test; Humans; Insulin Resistance; Liver - metabolism; Male; Medical sciences; Middle Aged; Obesity - metabolism; Original; Oxygen Consumption; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2007-1524

Context: Short-term aerobic exercise training can improve whole-body insulin sensitivity in humans with type 2 diabetes mellitus; however, the contributions of peripheral and hepatic tissues to these improvements are not known. Objective: Our objective was to determine the effect of 7-d aerobic exercise training on peripheral and hepatic insulin sensitivity during isoglycemic/hyperinsulinemic clamp conditions. Design: Subjects were randomly assigned to one of two groups. The energy balance group consumed an isocaloric diet consisting of 50% carbohydrate, 30% fat, and 20% protein for 15 d. The energy balance plus exercise group consumed a similar diet over the 15 d and performed 50-min of treadmill walking at 70% of maximum oxygen consumption maximum during the second 7 d of the 15-d study period. Each subject underwent an initial isoglycemic/hyperinsulinemic clamp after 1-wk dietary control and a second clamp after completing the study. Setting: The study was performed at Ohio State University’s General Clinical Research Center. Participants: There were 18 obese, mildly diabetic humans included in the study. Intervention: Aerobic exercise training was performed for 7 d. Main Outcome Measures: Whole-body, peripheral, and hepatic insulin sensitivity were measured. Results: Exercise training did not have an impact on peripheral glucose uptake or endogenous glucose production during the basal state or low-dose insulin. Likewise, it did not alter endogenous glucose production during high-dose insulin. However, 1-wk of exercise training increased both whole-body (P < 0.05) and peripheral insulin sensitivity (P < 0.0001) during high-dose insulin. Conclusion: Improvements to whole body insulin sensitivity after short-term aerobic exercise training are due to gains in peripheral, not heptic insulin sensitivity.