SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland

The pituitary gland adapts the proportion of each of its endocrine cell types to meet differing hormonal demands throughout life. There is circumstantial evidence that multipotent adult progenitor cells contribute to this plasticity, but these cells have not been identified. Here, we describe a smal...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2008-02, Vol.105 (8), p.2907-2912
Main Authors: Fauquier, Teddy, Rizzoti, Karine, Dattani, Mehul, Lovell-Badge, Robin, Robinson, Iain C.A.F
Format: Article
Language:English
Subjects:
Adult stem cells
Animals
Biological Sciences
Cell Differentiation - physiology
Cell division
Cell growth
Cell lines
Cells
Cellular differentiation
Chondrocytes
DNA-Binding Proteins - metabolism
Embryonic stem cells
Endocrine cells
HMGB Proteins - metabolism
Hormones
Mice
Microscopy, Confocal
Microscopy, Fluorescence
Multipotent stem cells
Pituitary gland
Pituitary Gland - cytology
Pituitary Gland - metabolism
Progenitor cells
Rodents
SOXB1 Transcription Factors
Stem cells
Stem Cells - cytology
Stem Cells - metabolism
Transcription Factors - metabolism
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Summary:The pituitary gland adapts the proportion of each of its endocrine cell types to meet differing hormonal demands throughout life. There is circumstantial evidence that multipotent adult progenitor cells contribute to this plasticity, but these cells have not been identified. Here, we describe a small (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0707886105