GENDER AND ADOLESCENT ALCOHOL USE DISORDERS ON BOLD (BLOOD OXYGEN LEVEL DEPENDENT) RESPONSE TO SPATIAL WORKING MEMORY

Aims: To determine how alcohol use differentially affects brain functioning in male and female adolescents. Methods: Adolescents with alcohol use disorders (AUDs; 7 female, 11 male) and control adolescents without AUDs (9 female, 12 male), aged 14–17 years, performed spatial working memory and vigil...

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Published in:Alcohol and alcoholism (Oxford) 2005-05, Vol.40 (3), p.194-200
Main Authors: CALDWELL, LISA C., SCHWEINSBURG, ALECIA D., NAGEL, BONNIE J., BARLETT, VALERIE C., BROWN, SANDRA A., TAPERT, SUSAN F.
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Alcohol related disorders
Alcohol-Related Disorders - blood
Alcohol-Related Disorders - physiopathology
Alcohol-Related Disorders - psychology
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Brain activity
Female
Functional magnetic resonance imaging
Gender differences
Humans
Magnetic Resonance Imaging - methods
Male
Medical sciences
Memory - physiology
Oxygen - blood
Oxygen Consumption - physiology
Risk factors
Sex Characteristics
Spatial Behavior - physiology
Spatial task performance
Toxicology
Vigilance
Working memory
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Summary:Aims: To determine how alcohol use differentially affects brain functioning in male and female adolescents. Methods: Adolescents with alcohol use disorders (AUDs; 7 female, 11 male) and control adolescents without AUDs (9 female, 12 male), aged 14–17 years, performed spatial working memory and vigilance tasks during functional magnetic resonance imaging. Results: Gender, AUD and their interaction were significantly associated with brain activation patterns to the tasks. There were interactions in the superior frontal, superior temporal, cingulate and fusiform regions, in which female and male adolescents with AUDs showed a different brain response from each other and control subjects. Overall, female adolescents with AUDs showed a greater departure from normal activation patterns than male adolescents with AUD. Conclusions: Adolescent alcohol involvement may affect male and female brains differently, and adolescent females may be somewhat more vulnerable to adverse alcohol effects. With continued drinking, these adolescents may be at an increased risk for behavioural deficits.
ISSN:0735-0414
1464-3502
DOI:10.1093/alcalc/agh134