Survey of fox trappers in northern Alaska for rabies antibody

• Published in: Epidemiology and infection 1994-08, Vol.113 (1), p.137-141
• Main Authors: Follmann, E. H., Ritter, D. G., Beller, M.
• Format: Article
• Language: English
• Subjects: Acquired immunity; Adult; Aged; Alaska - epidemiology; Animals; Antibodies; Antibodies, Viral - blood; Biological and medical sciences; Female; Foxes; Fundamental and applied biological sciences. Psychology; Handling (Psychology); Humans; Immunity, Active; Male; Microbiology; Middle Aged; Neutralizing antibodies; Public health; Rabies; Rabies - epidemiology; Rabies - immunology; Rabies Vaccines - administration & dosage; Rabies Vaccines - immunology; Rabies virus; Rabies virus - immunology; Techniques used in virology; Vaccination; Virology
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268800051554

The purpose of this research was to determine whether trappers in northern Alaska acquired immunity to rabies virus from non-bite exposures while trapping and skinning arctic foxes (Alopex lagopus). In coastal Alaska recurring epizootics presumably provide trappers ample opportunity for contact with rabid animals. Serum neutralization analyses of blood samples collected from 26 individuals were conducted. All but three had negative rabies neutralizing antibody levels (< 0·05 I.U./ml). Two of these had previously received rabies vaccine but one individual who had trapped for about 47 years with an estimated harvest of over 3000 foxes and who had never received pre- or post-exposure rabies vaccination had a rabies serum neutralizing antibody concentration of 2·30 I.U./ml. This represents the first report of an unvaccinated person acquiring rabies virus antibody with a titre above the 0·5 I.U./ml level considered acceptable by the World Health Organization.