Antimicrobial susceptibilities and serotyping of Neisseria gonorrhoeae in southern Africa: influence of geographical source of infection

One hundred and ninety-two strains of Neisseria gonorrhoeae isolated from migrant mine-workers were tested for their susceptibility to antibiotics, auxotyped and serotyped. Of the total, 93 (48%) were acquired locally and 64 (33%) from different geographical locations. Plasmid-mediated resistance to...

Full description

Saved in:
Bibliographic Details
Published in:Epidemiology and infection 1993-04, Vol.110 (2), p.297-305
Main Authors: Ison, C. A., Roope, N. S., Dangor, Y., Radebe, F., Ballard, R.
Format: Article
Language:English
Subjects:
Africa, Southern - epidemiology
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobials
Bacteriology
Biological and medical sciences
Cephalosporins
Drug Resistance, Microbial
Epidemiology
Fundamental and applied biological sciences. Psychology
Gonorrhea - epidemiology
Gonorrhea - microbiology
Humans
Infections
Microbial Sensitivity Tests
Microbiology
Monoclonal antibodies
Neisseria gonorrhoeae
Neisseria gonorrhoeae - classification
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - growth & development
Penicillin
Penicillin Resistance
Plasmids
Plasmids - drug effects
Prevalence
Serotyping
Sexually transmitted diseases
Urethritis - microbiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:One hundred and ninety-two strains of Neisseria gonorrhoeae isolated from migrant mine-workers were tested for their susceptibility to antibiotics, auxotyped and serotyped. Of the total, 93 (48%) were acquired locally and 64 (33%) from different geographical locations. Plasmid-mediated resistance to penicillin was found in 28 (14·6%) strains and was associated predominantly with the presence of 5·0 kb penicillinase encoding plasmid (18/28, 64%). Chromosomal resistance to penicillin (MIC ≥ 1 mg/l) was detected in 14 (7·3%) strains. Resistance to tetracycline was chromosomally and not plasmid-mediated. Antibiotic resistance was encountered most commonly among strains acquired in Natal. The overall gonococcal population was sensitive to ceftriaxone, ciprofloxacin. spectinomycin and azithromycin. Nine auxotype/serovar (A/S) classes were encountered among penicillinase-producing N. gonorrhoeae (PPNG) compared to 24 A/S classes among non-PPNG strains. The most common A/S class was NR/IA-6 which accounted for 38% of PPNG and 15% of non-PPNG.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268800068230