Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors

The optimization of GS39783 into potent, selective and safe positive allosteric modulators of GABA B receptors is presented.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-11, Vol.17 (22), p.6206-6211
Main Authors: GUERY, Sébastien, FLOERSHEIM, Philipp, KAUPMANN, Klemens, FROESTL, Wolfgang
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug addictions
Gabaergic and benzodiazepinic system
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Toxicology
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Description
Summary:The optimization of GS39783 into potent, selective and safe positive allosteric modulators of GABA B receptors is presented.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.09.023