MicroCT for high‐resolution imaging of ectopic pheochromocytoma tumors in the liver of nude mice

Successful outcomes for patients with cancer often depend on the early detection of tumor and the prompt initiation of active therapy. Despite major advances in the treatment of many cancers, early‐stage lesions often go undetected due to the suboptimal resolution of current anatomical and functiona...

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Bibliographic Details
Published in:International journal of cancer 2006-11, Vol.119 (9), p.2236-2241
Main Authors: Ohta, Shoichiro, Lai, Edwin W., Morris, John C., Bakan, Douglas A., Klaunberg, Brenda, Cleary, Susannah, Powers, James F., Tischler, Arthur S., Abu‐Asab, Mones, Schimel, Daniel, Pacak, Karel
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - diagnostic imaging
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Contrast Media
Experimental digestive system and abdominal tumors
Image Processing, Computer-Assisted
Liver Neoplasms - diagnostic imaging
liver tumor
Medical sciences
Mice
Mice, Nude
microCT
mouse model
pheochromocytoma
Pheochromocytoma - diagnostic imaging
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
Tumors
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Summary:Successful outcomes for patients with cancer often depend on the early detection of tumor and the prompt initiation of active therapy. Despite major advances in the treatment of many cancers, early‐stage lesions often go undetected due to the suboptimal resolution of current anatomical and functional imaging modalities. This limitation also applies to preclinical animal tumor models that are crucial for the evaluation and development of new therapeutic approaches to cancer. We report a new mouse model of metastatic pheochromocytoma, generated using tail vein injection of the mouse pheochromocytoma cell (MPC) line that reproducibly generated multiple liver tumors in the animals. Furthermore, we show that in vivo microCT imaging enhanced using a hepatobiliary‐specific contrast agent, glyceryl‐2‐oleyl‐1,3‐di‐7‐(3‐amino‐2,4,6‐triiodophenyl)‐heptanoate (DHOG), detected tumors as small as 0.35 mm as early as 4 weeks after the injection of the tumor cells. This model may be useful for in vivo studies of tumor biology and for development of new strategies to treat metastatic pheochromocytoma. © 2006 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.22127