Breast tumor characteristics of BRCA1 and BRCA2 gene mutation carriers on MRI

The appearance of malignant lesions in BRCA1 and BRCA2 mutation carriers (BRCA-MCs) on mammography and magnetic resonance imaging (MRI) was evaluated. Thus, 29 BRCA-MCs with breast cancer were retrospectively evaluated and the results compared with an age, tumor size and tumor type matched control g...

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Bibliographic Details
Published in:European radiology 2008-05, Vol.18 (5), p.931-938
Main Authors: Veltman, J., Mann, R., Kok, T., Obdeijn, I. M., Hoogerbrugge, N., Blickman, J. G., Boetes, C.
Format: Article
Language:English
Subjects:
Adult
Breast
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Case-Control Studies
Contrast Media
Diagnostic Radiology
False Negative Reactions
Female
Gadolinium DTPA
Genes, BRCA1
Genes, BRCA2
Humans
Image Processing, Computer-Assisted
Imaging
Internal Medicine
Interventional Radiology
Magnetic Resonance Imaging
Mammography
Medicine
Medicine & Public Health
Mutation
Neuroradiology
Radiology
Retrospective Studies
Ultrasound
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Summary:The appearance of malignant lesions in BRCA1 and BRCA2 mutation carriers (BRCA-MCs) on mammography and magnetic resonance imaging (MRI) was evaluated. Thus, 29 BRCA-MCs with breast cancer were retrospectively evaluated and the results compared with an age, tumor size and tumor type matched control group of 29 sporadic breast cancer cases. Detection rates on both modalities were evaluated. Tumors were analyzed on morphology, density (mammography), enhancement pattern and kinetics (MRI). Overall detection was significantly better with MRI than with mammography (55/58 vs 44/57, P  = 0.021). On mammography, lesions in the BRCA-MC group were significantly more described as rounded (12//19 vs 3/13, P  = 0.036) and with sharp margins (9/19 vs 1/13, P  = 0.024). On MRI lesions in the BRCA-MC group were significantly more described as rounded (16/27 vs 7/28, P  = 0.010), with sharp margins (20/27 vs 7/28, P  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-008-0851-y