Intraoperative anticoagulation management during cardiac transplantation for a patient with heparin-induced thrombocytopenia and a left ventricular assist device

Heparin-induced thrombocytopenia is an immunologically mediated syndrome that is associated with potentially life-threatening arterial and venous thrombosis. Re-exposing patients who have heparin-induced thrombocytopenia to heparin during cardiopulmonary bypass may be hazardous. We describe the re-e...

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Bibliographic Details
Published in:Texas Heart Institute journal 2008, Vol.35 (1), p.62-65
Main Authors: Wadia, Yasmin, Cooper, John R, Bracey, Arthur W, Pinto, Katheleen, Frazier, O H
Format: Article
Language:English
Subjects:
Anticoagulants - administration & dosage
Anticoagulants - adverse effects
Cardiomyopathy, Dilated - surgery
Cardiopulmonary Bypass
Case Reports
Female
Fibrin Fibrinogen Degradation Products - analysis
Fibrinogen - analysis
Heart Transplantation - methods
Heart-Assist Devices
Heparin - administration & dosage
Heparin - adverse effects
Hirudins - administration & dosage
Humans
Intraoperative Period
Middle Aged
Recombinant Proteins - administration & dosage
Thrombocytopenia - chemically induced
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Description
Summary:Heparin-induced thrombocytopenia is an immunologically mediated syndrome that is associated with potentially life-threatening arterial and venous thrombosis. Re-exposing patients who have heparin-induced thrombocytopenia to heparin during cardiopulmonary bypass may be hazardous. We describe the re-exposure to unfractionated heparin of a patient with a left ventricular assist device and evidence of heparin-induced thrombocytopenia who needed cardiac transplantation, which was accomplished without complications.
ISSN:0730-2347
0730-2347