The Assessment of Autoimmunological Status and Prevalence of Different Forms of Celiac Disease among Children with Type 1 Diabetes Mellitus and Celiac Disease

This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM) . The study group comprises 27 patients at the mean age of 12.30 years (±SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specif...

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Bibliographic Details
Published in:Mediators of Inflammation 2008-01, Vol.2008 (2008), p.119-124
Main Authors: Siekiera, Urszula, Jarosz-Chobot, Przemyslawa, Myrda, Anna, Deja, Grazyna
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Autoantibodies - immunology
Biological and medical sciences
Celiac Disease - complications
Celiac Disease - epidemiology
Celiac Disease - immunology
Child
Comorbidity
Diabetes Mellitus, Type 1 - complications
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Male
Medical sciences
Other diseases. Semiology
Poland - epidemiology
Prevalence
Retrospective Studies
Risk Factors
Sex Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Thyroiditis - complications
Thyroiditis - epidemiology
Thyroiditis - immunology
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Summary:This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM) . The study group comprises 27 patients at the mean age of 12.30 years (±SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD (r=‐0.35, p
ISSN:0962-9351
1466-1861
DOI:10.1155/2008/285989