Effect of CD8+ T‐cell depletion on bronchial hyper‐responsiveness and inflammation in sensitized and allergen‐exposed Brown–Norway rats

We examined the role of CD8+ T cells in a Brown–Norway rat model of asthma, using a monoclonal antibody to deplete CD8+ T cells. Ovalbumin (OA)‐sensitized animals were given anti‐CD8 antibody (0·5 mg/rat) intravenously 1 week prior to exposure to 1% OA aerosol and were studied 18–24 hr after aerosol...

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Bibliographic Details
Published in:Immunology 1999-03, Vol.96 (3), p.416-423
Main Authors: Huang, T J, MacAry, P A, Kemeny, D M, Chung, K F
Format: Article
Language:English
Subjects:
Acetylcholine - immunology
AIDS/HIV
Allergens - immunology
Animals
Antibodies, Monoclonal - immunology
Asthma - immunology
Asthma - physiopathology
Blotting, Southern
Bronchial Hyperreactivity - immunology
Bronchoalveolar Lavage Fluid - immunology
CD8-Positive T-Lymphocytes - immunology
Cytokines - biosynthesis
Immunoenzyme Techniques
Lung - immunology
Lymphocyte Count
Male
Mice
Original
Ovalbumin - immunology
Rats
Rats, Inbred BN
Reverse Transcriptase Polymerase Chain Reaction
Vasodilator Agents - immunology
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Summary:We examined the role of CD8+ T cells in a Brown–Norway rat model of asthma, using a monoclonal antibody to deplete CD8+ T cells. Ovalbumin (OA)‐sensitized animals were given anti‐CD8 antibody (0·5 mg/rat) intravenously 1 week prior to exposure to 1% OA aerosol and were studied 18–24 hr after aerosol exposure. Following administration of anti‐CD8 antibody, CD8+ cells were reduced to
ISSN:0019-2805
1365-2567
DOI:10.1046/j.1365-2567.1999.00699.x