Hexammineruthenium(III) ion interactions with Z-DNA

The hexamer duplex d(CGCGCA)·d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 Å resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A·T base...

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Bibliographic Details
Published in:Acta crystallographica. Section F, Structural biology and crystallization communications Structural biology and crystallization communications, 2007-12, Vol.63 (12), p.1008-1013
Main Authors: Bharanidharan, D., Thiyagarajan, S., Gautham, N.
Format: Article
Language:English
Subjects:
CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
Crystallography, X-Ray
CRYSTALS
DNA
DNA, Z-Form - chemistry
hexammineruthenium(III) ion
INTERACTIONS
IONS
Ions - chemistry
METALS
Models, Molecular
Nucleic Acid Conformation
Nucleic Acid Structure Communications
RESOLUTION
Ruthenium Compounds - chemistry
SPACE GROUPS
tautomeric shift
TOXICITY
Z-DNA
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Description
Summary:The hexamer duplex d(CGCGCA)·d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 Å resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A·T base pairing is disrupted. This structural study may be relevant to metal toxicity.
ISSN:1744-3091
1744-3091
DOI:10.1107/S1744309107047781