Reproducibility of quantitative tractography methods applied to cerebral white matter

Tractography based on diffusion tensor imaging (DTI) allows visualization of white matter tracts. In this study, protocols to reconstruct eleven major white matter tracts are described. The protocols were refined by several iterations of intra- and inter-rater measurements and identification of sour...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2007-07, Vol.36 (3), p.630-644
Main Authors: Wakana, Setsu, Caprihan, Arvind, Panzenboeck, Martina M., Fallon, James H., Perry, Michele, Gollub, Randy L., Hua, Kegang, Zhang, Jiangyang, Jiang, Hangyi, Dubey, Prachi, Blitz, Ari, van Zijl, Peter, Mori, Susumu
Format: Article
Language:English
Subjects:
Adult
Anisotropy
Asymmetry
Attention deficit hyperactivity disorder
Brain
Brain - anatomy & histology
Cell Count
Data processing
Databases, Factual
Diffusion Magnetic Resonance Imaging
Diffusion tensor imaging
Female
Gyrus Cinguli - cytology
Gyrus Cinguli - physiology
Hippocampus - cytology
Hippocampus - physiology
Humans
Image Processing, Computer-Assisted
Male
Methods
Nerve Fibers - physiology
Neural Pathways - anatomy & histology
Noise
Observer Variation
Pyramidal Tracts - anatomy & histology
Pyramidal Tracts - physiology
Reference Values
Reproducibility
Reproducibility of Results
Studies
Thalamus - anatomy & histology
Thalamus - physiology
Tractography
Validity
White matter
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Description
Summary:Tractography based on diffusion tensor imaging (DTI) allows visualization of white matter tracts. In this study, protocols to reconstruct eleven major white matter tracts are described. The protocols were refined by several iterations of intra- and inter-rater measurements and identification of sources of variability. Reproducibility of the established protocols was then tested by raters who did not have previous experience in tractography. The protocols were applied to a DTI database of adult normal subjects to study size, fractional anisotropy (FA), and T2 of individual white matter tracts. Distinctive features in FA and T2 were found for the corticospinal tract and callosal fibers. Hemispheric asymmetry was observed for the size of white matter tracts projecting to the temporal lobe. This protocol provides guidelines for reproducible DTI-based tract-specific quantification.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2007.02.049