Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression

The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo 19 F-magnetic resonance spectroscopy measurements a...

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Bibliographic Details
Published in:British journal of cancer 2007-03, Vol.96 (5), p.758-761
Main Authors: Dubois, L, Dresselaers, T, Landuyt, W, Paesmans, K, Mengesha, A, Wouters, B G, Hecke, P Van, Theys, J, Lambin, P
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - analysis
Antineoplastic Agents - metabolism
Antineoplastic Agents - therapeutic use
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blotting, Western
Cancer Research
Cancer therapies
Chromatography
Chromatography, Thin Layer
Cytosine Deaminase - genetics
Cytosine Deaminase - therapeutic use
Drug Resistance
Epidemiology
Female
Flucytosine - analysis
Flucytosine - metabolism
Flucytosine - therapeutic use
Fluorouracil - analysis
Fluorouracil - metabolism
Fluorouracil - therapeutic use
Gene therapy
Genetic Therapy - methods
Genetic Vectors
Human bacterial diseases
Humans
Hypoxia
Infectious diseases
Magnetic Resonance Spectroscopy
Medical research
Medical sciences
Mice
Molecular Medicine
Neoplasms, Experimental - therapy
Oncology
Prodrugs - analysis
Prodrugs - metabolism
Prodrugs - therapeutic use
Salmonella
Salmonella typhimurium
Salmonella typhimurium - genetics
Spectrum analysis
Statistical significance
Translational Therapeutics
Tumors
Xenograft Model Antitumor Assays
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Summary:The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo 19 F-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603624