OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome

Laryngeal dysplasia is a common clinical concern. Despite major advancements, a significant number of patients with this condition progress to invasive squamous cell carcinoma. Osteopontin (OPN) is a secreted glycoprotein, whose expression is markedly elevated in several types of cancers. We explore...

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Bibliographic Details
Published in:British journal of cancer 2007-12, Vol.97 (11), p.1545-1551
Main Authors: Staibano, S, Merolla, F, Testa, D, Iovine, R, Mascolo, M, Guarino, V, Castellone, M D, Di Benedetto, M, Galli, V, Motta, S, Melillo, R M, De Rosa, G, Santoro, M, Celetti, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Clinical outcomes
Disease-Free Survival
Drug Resistance
Epidemiology
Female
Glycoproteins - analysis
Humans
Hyaluronan Receptors - analysis
Immunohistochemistry
Laryngeal Diseases - metabolism
Laryngeal Diseases - pathology
Male
Medical sciences
Middle Aged
Molecular Diagnostics
Molecular Medicine
Oncology
Osteopontin - analysis
Pharyngeal Neoplasms - metabolism
Pharyngeal Neoplasms - pathology
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
Prognosis
Tumors
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Summary:Laryngeal dysplasia is a common clinical concern. Despite major advancements, a significant number of patients with this condition progress to invasive squamous cell carcinoma. Osteopontin (OPN) is a secreted glycoprotein, whose expression is markedly elevated in several types of cancers. We explored OPN as a candidate biomarker for laryngeal dysplasia. To this aim, we examined OPN expression in 82 cases of dysplasia and in hyperplastic and normal tissue samples. OPN expression was elevated in all severe dysplasia samples, but not hyperplastic samples, with respect to matched normal mucosa. OPN expression levels correlated positively with degree of dysplasia ( P =0.0094) and negatively with disease-free survival ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604070