Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications

Minichromosome maintenance proteins (MCM) have recently emerged as novel proliferation markers with prognostic implications in several tumour types. This is the first study investigating MCM-2 and MCM-5 immunohistochemical expression in a series of ovarian adenocarcinomas and low malignant potential...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2007-10, Vol.97 (8), p.1124-1134
Main Authors: Gakiopoulou, H, Korkolopoulou, P, Levidou, G, Thymara, I, Saetta, A, Piperi, C, Givalos, N, Vassilopoulos, I, Ventouri, K, Tsenga, A, Bamias, A, Dimopoulos, M-A, Agapitos, E, Patsouris, E
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor - analysis
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell cycle
Cell Cycle Proteins - metabolism
Drug Resistance
Epidemiology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Medical prognosis
Medical research
Medical sciences
Middle Aged
Minichromosome Maintenance Complex Component 2
Molecular Diagnostics
Molecular Medicine
Neoplasm Staging
Neoplasms, Glandular and Epithelial - metabolism
Neoplasms, Glandular and Epithelial - mortality
Neoplasms, Glandular and Epithelial - pathology
Nuclear Proteins - metabolism
Oncology
Ovarian cancer
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - mortality
Ovarian Neoplasms - pathology
Prognosis
Proteins
Survival analysis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Minichromosome maintenance proteins (MCM) have recently emerged as novel proliferation markers with prognostic implications in several tumour types. This is the first study investigating MCM-2 and MCM-5 immunohistochemical expression in a series of ovarian adenocarcinomas and low malignant potential (LMP) tumours aiming to determine possible associations with clinicopathological parameters, the conventional proliferation index Ki-67, cell cycle regulators (p53, p27 Kip1 , p21 WAF1 and pRb) and patients’ outcome. Immunohistochemistry was applied in a series of 43 cases of ovarian LMP tumours and 85 cases of adenocarcinomas. Survival analysis was restricted to adenocarcinomas. The median MCM-2 and MCM-5 labelling indices (LIs) were significantly higher in adenocarcinomas compared to LMP tumours ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603992