First and subsequent asbestos exposures in relation to mesothelioma and lung cancer mortality

We analysed data from a cohort of 1966 subjects (889 men and 1077 women) employed by an Italian asbestos (mainly textile) company in the period 1946–1984, who were followed-up to 2004. A total of 62 025 person-years of observation were recorded. We computed standardised mortality ratios (SMR) for al...

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Bibliographic Details
Published in:British journal of cancer 2007-11, Vol.97 (9), p.1300-1304
Main Authors: Pira, E, Pelucchi, C, Piolatto, P G, Negri, E, Discalzi, G, La Vecchia, C
Format: Article
Language:English
Subjects:
Adult
Asbestos - adverse effects
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cohort Studies
Drug Resistance
Epidemiology
Female
Humans
Italy - epidemiology
Lung cancer
Lung Neoplasms - etiology
Lung Neoplasms - mortality
Male
Medical sciences
Mesothelioma - etiology
Mesothelioma - mortality
Molecular Medicine
Occupational Diseases - etiology
Occupational Diseases - mortality
Occupational Exposure
Oncology
Peritoneal Neoplasms - etiology
Peritoneal Neoplasms - mortality
Pleural Neoplasms - etiology
Pleural Neoplasms - mortality
Pneumology
Survival Rate
Time Factors
Tumors
Tumors of the respiratory system and mediastinum
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Summary:We analysed data from a cohort of 1966 subjects (889 men and 1077 women) employed by an Italian asbestos (mainly textile) company in the period 1946–1984, who were followed-up to 2004. A total of 62 025 person-years of observation were recorded. We computed standardised mortality ratios (SMR) for all causes and selected cancer sites using national death rates for each 5-year calendar period and age group. There were 68 deaths from mesothelioma (25 men and 43 women, 39 pleural and 29 peritoneal) vs 1.6 expected (SMR=4159), and 109 from lung cancer vs 35.1 expected (SMR=310). The SMRs of pleural/peritoneal cancer were 6661 for subjects exposed only before 30 years of age, 8019 for those first exposed before 30 and still employed at 30–39 years of age and 5786 for those first exposed before 30 and still employed at 40 or more years of age. The corresponding SMRs for lung cancer were 227, 446 and 562. The SMR of mesothelioma was strongly related to time since first exposure. The SMR of lung cancer, but not of mesothelioma, appeared to be related to subsequent exposures.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603998