Morphological and molecular assessment of apoptotic mechanisms in peripheral neuroblastic tumours

Multiple defects in apoptotic pathways have been described in peripheral neuroblastic tumours (NTs). Mitosis–karyorrhexis index (MKI) is a reliable morphological marker identifying favourable and unfavourable NTs. The extent to which apoptotic processes contribute to determine the clinical significa...

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Bibliographic Details
Published in:British journal of cancer 2006-07, Vol.95 (1), p.49-55
Main Authors: Uccini, S, Colarossi, C, Scarpino, S, Boldrini, R, Natali, P G, Nicotra, M R, Perla, F M, Mannarino, O, Altavista, P, Boglino, C, Cappelli, C A, Cozzi, D, Donfrancesco, A, Kokai, G, Losty, P D, McDowell, H P, Dominici, C
Format: Article
Language:English
Subjects:
Adolescent
Apoptosis
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell Proliferation
Child
Child, Preschool
Drug Resistance
Epidemiology
Female
Gene Expression Profiling
Humans
Infant
Infant, Newborn
Male
Medical sciences
Mitotic Index
Molecular Diagnostics
Molecular Medicine
Neuroblastoma - diagnosis
Neuroblastoma - genetics
Neuroblastoma - metabolism
Neurology
Oligonucleotide Array Sequence Analysis
Oncology
Peripheral Nervous System Neoplasms - diagnosis
Peripheral Nervous System Neoplasms - genetics
Peripheral Nervous System Neoplasms - metabolism
Predictive Value of Tests
Prognosis
Survival Analysis
Tumors
Tumors of the nervous system. Phacomatoses
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Summary:Multiple defects in apoptotic pathways have been described in peripheral neuroblastic tumours (NTs). Mitosis–karyorrhexis index (MKI) is a reliable morphological marker identifying favourable and unfavourable NTs. The extent to which apoptotic processes contribute to determine the clinical significance of MKI is still undefined. Apoptosis was investigated in a series of 110 peripheral NTs by comparing MKI to immunohistochemical and molecular apoptotic features. High MKI was found in 55 out of 110 NTs (50%) and was associated with advanced stage ( P =0.007), neuroblastoma (NB) histological category ( P =0.024), MYCN amplification ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603212