Increased risk of second malignancies after in situ breast carcinoma in a population-based registry

Among 1276 primary breast carcinoma in situ (BCIS) patients diagnosed in 1972–2002 in the Southern Netherlands, 11% developed a second cancer. Breast carcinoma in situ patients exhibited a two-fold increased risk of second cancer (standardised incidence ratios (SIR): 2.1, 95% confidence interval (CI...

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Bibliographic Details
Published in:British journal of cancer 2006-08, Vol.95 (3), p.393-397
Main Authors: Soerjomataram, I, Louwman, W J, van der Sangen, M J C, Roumen, R M H, Coebergh, J W W
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Breast Neoplasms - diagnosis
Breast Neoplasms - epidemiology
Breast Neoplasms - therapy
Cancer Research
Carcinoma in Situ - diagnosis
Carcinoma in Situ - epidemiology
Carcinoma in Situ - therapy
Cohort Studies
Drug Resistance
Epidemiology
Female
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
Molecular Medicine
Neoplasm Invasiveness
Neoplasms, Second Primary - diagnosis
Neoplasms, Second Primary - epidemiology
Oncology
Population Surveillance
Registries - standards
Registries - statistics & numerical data
Risk Factors
Tumors
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Summary:Among 1276 primary breast carcinoma in situ (BCIS) patients diagnosed in 1972–2002 in the Southern Netherlands, 11% developed a second cancer. Breast carcinoma in situ patients exhibited a two-fold increased risk of second cancer (standardised incidence ratios (SIR): 2.1, 95% confidence interval (CI): 1.7–2.5). The risk was highest for a second breast cancer (SIR: 3.4, 95% CI: 2.6–4.3; AER: 66 patients per 10 000 per year) followed by skin cancer (SIR: 1.7, 95% CI: 1.1–2.6; AER: 17 patients per 10 000 per year). The increased risk of second breast cancer was similar for the ipsilateral (SIR: 1.9, 95% CI: 1.3–2.7) and contralateral (SIR: 2.0, 95% CI: 1.4–2.8) breast. Risk of second cancer was independent of age at diagnosis, type of initial therapy, histologic type of BCIS and period of diagnosis. Standardised incidence ratios of second cancer after BCIS (SIR: 2.3, 95% CI: 1.8–2.8) resembled that after invasive breast cancer (SIR: 2.2, 95% CI: 2.1–2.4). Surveillance should be directed towards second (ipsi- and contra-lateral) breast cancer.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603231