Fever, hepatosplenomegaly and pancytopenia in a patient living in the Mediterranean region

A 24 year old woman living in the Mediterranean region of Turkey present with a three-month history of weight loss and irregular fever that was peaking at 40 degrees C with shivering. No definite aetiology could be identified in a local hospital. A bacterial infection had been suspected, but antibio...

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Published in:Postgraduate medical journal 1998-04, Vol.74 (870), p.237-239
Main Authors: Büyükaşik, Y., Ileri, N. S., Haznedaroğlu, I. C., Demiroğlu, H., Dündar, S.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Fever - parasitology
Hepatomegaly - parasitology
Human protozoal diseases
Humans
Infectious diseases
Leishmaniasis, Visceral - complications
Leishmaniasis, Visceral - diagnosis
Leshmaniasis
Medical sciences
Pancytopenia - parasitology
Parasitic diseases
Protozoal diseases
Splenomegaly - parasitology
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cited_by cdi_FETCH-LOGICAL-b518t-cd515abb5f6e995f6514c56dbf54f80b4375ea2fdbd97eefc214b2cc30d0fe613
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container_start_page 237
container_title Postgraduate medical journal
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creator Büyükaşik, Y.
Ileri, N. S.
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Dündar, S.
description A 24 year old woman living in the Mediterranean region of Turkey present with a three-month history of weight loss and irregular fever that was peaking at 40 degrees C with shivering. No definite aetiology could be identified in a local hospital. A bacterial infection had been suspected, but antibiotic therapy, at first with sulbactam-ampicillin and later with azithromycin, had no influence on the fever. Physical examination revealed an emaciated patient with fever (39 degrees C), pallor, and hepatosplenomegaly (spleen 9 cm and liver 5 cm palpable below the costal margin). No peripheral lymphadenopathy was present. The laboratory examinations are summarised in the table. Notably, a prominent increase of macrophages containing intracellular micro-organisms (figures 1 and 2) was seen in the bone marrow smears. The same micro-organisms were also identified within the Kupffer cells in liver biopsy.
doi_str_mv 10.1136/pgmj.74.870.237
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subjects Adult
Biological and medical sciences
Female
Fever - parasitology
Hepatomegaly - parasitology
Human protozoal diseases
Humans
Infectious diseases
Leishmaniasis, Visceral - complications
Leishmaniasis, Visceral - diagnosis
Leshmaniasis
Medical sciences
Pancytopenia - parasitology
Parasitic diseases
Protozoal diseases
Splenomegaly - parasitology
title Fever, hepatosplenomegaly and pancytopenia in a patient living in the Mediterranean region
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